Effect of sub-MICs of macrolides on the sensitivity of Pseudomonas aeruginosa to nitrosative stress: effectiveness against P. aeruginosa with and without multidrug resistance.
Effect of sub-MICs of macrolides on the sensitivity of Pseudomonas aeruginosa to nitrosative stress: effectiveness against P. aeruginosa with and without multidrug resistance.
复制标题
大环内酯类的亚 MIC 对铜绿假单胞菌亚硝化应激敏感性的影响：对具有和不具有多重耐药性的铜绿假单胞菌的有效性。
DOI：
10.1128/aac.01180-20
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
and Akio Matsumoto
中科院分区：
文献类型：
--
作者：
Takeshi Shimizu;Tohru Miyoshi-Akiyama;Kohei Ogura;Shota Murata;Shota Ishige;Kiyohiro Kai;Konosuke Mitsutsuka;Haruyoshi Tomita;Koichi Tanimoto;and Akio Matsumoto
14元大环内酯红霉素（EM）和克拉霉素（CAM）的亚MIC抑制铜绿假单胞菌PAO 1的生长，并增加其对内源性和外源性亚硝化应激的敏感性。然而，16元大环内酯，交沙霉素（JM），没有或较少有效。在13个非多药耐药铜绿假单胞菌（非MDRP）中的9个和27个MDRP ST 235菌株中的9个中，EM的亚MIC在用一氧化氮供体处理后诱导细菌数量显著减少。
Sub-MICs of the 14-membered macrolides erythromycin (EM) and clarithromycin (CAM) decreased the growth of Pseudomonas aeruginosa PAO1 and increased its sensitivity to endogenous and exogenous nitrosative stress. However, a 16-membered macrolide, josamycin (JM), was not or less effective. In 9 of 13 non-multidrug-resistant P. aeruginosa (non-MDRP) and 9 of 27 MDRP ST235 strains, the sub-MIC of EM induced significant reductions in bacterial numbers following treatment with a nitric oxide donor.