A clickable caging group as a new platform for modular caged compounds with improved photochemical properties
A clickable caging group as a new platform for modular caged compounds with improved photochemical properties
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可点击笼组作为模块化笼化合物的新平台，具有改进的光化学性能
DOI：
10.1039/c8cc07981a
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发表时间：
2019
影响因子：
4.9
通讯作者：
Toshiaki Furuta
中科院分区：
文献类型：
--
作者：
Akinobu Z. Suzuki;Ryota Sekine;Shiori Takeda;Ryosuke Aikawa;Yukiko Shiraishi;Tomomi Hamaguchi;Hiroyuki Okuno;Hirokazu Tamamura;Toshiaki Furuta
设计并合成了一种具有点击修饰化学手柄的6-溴-7-羟基香豆素-4-基甲基（Bhc）笼状化合物。该分子被应用于合成模块化笼状紫杉醇（PTX），其中可以很容易地安装额外的功能单元。该系统用于制备具有改善的光解效率的水溶性笼状PTX。
A 6-bromo-7-hydroxycoumarin-4-ylmethyl (Bhc) caged compound having a click-modifiable chemical handle was designed and synthesized. This molecule was applied to the synthesis of modular caged paclitaxels (PTXs) in which additional functional units could be easily installed. This system was used to prepare water-soluble caged PTXs with improved photolysis efficiencies.