Effects of intravenous calcitonin gene-related peptide (CGRP) on local blood flow in the cat.
Effects of intravenous calcitonin gene-related peptide (CGRP) on local blood flow in the cat.
复制标题
静脉注射降钙素基因相关肽（CGRP）对猫局部血流的影响。
DOI：
10.1111/j.1748-1716.1989.tb08747.x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Andersson,SE
中科院分区：
文献类型：
--
作者：
Andersson,SE
I的影响。采用微球法研究了降钙素基因相关肽（CGRP）对猫局部血流量、血管阻力、心率和心输出量的影响。进行了三个系列的实验。在第一组中，没有对动物进行预处理。在第二组中，用吲哚美辛（5 mg kg-1）预处理动物，以防止形成洋地黄素。在第三个系列中，给予神经节阻滞剂溴化六甲双铵（80 mg kg-1）以预防自主神经反射。CGRP作为i. v.输液。在每个系列中测试两个剂量。未经预处理的动物和经吲哚美辛预处理的动物首先在5分钟内输注60 pmol kg-1，然后在3分钟内输注180 pmol kg-1。接受神经节阻滞的动物接受与其他系列相同的总输注剂量（240 pmol kg-1），输注时间为4 min，第二次输注剂量为1.2 nmol kg-1，输注时间为5 min。在大多数受试组织中观察到血管舒张作用，但敏感性存在显著差异。最敏感的组织似乎是泪腺、颌下腺和腮腺、瞬膜、舌和胆囊。敏感性的模式是相似的，在所有的系列，表明既不arylandins，也不自主反射参与的effects.In实验中的动物神经节阻滞下，血压升高，伴随着心率的增加，被认为是5分钟后输注结束。因此，很可能该肽对猫心脏发挥直接的正性变时作用。
The effects of i. v. calcitonin gene‐related peptide (CGRP) on regional blood flow, vascular resistance, heart rate and cardiac output in cats were studied using the microsphere method. Three series of experiments were performed. In the first there was no pre‐treatment of the animals. In the second the animals were pre‐treated with indomethacin (5 mg kg‐1) in order to prevent the formation of prostaglandins. In the third series the ganglionic blocking agent hexamethonium bromide (80 mg kg‐1) was given in order to prevent autonomic reflexes. CGRP was given as an i. v. infusion. Two doses were tested in each series. Animals with no pre‐treatment and those pre‐treated with indomethacin received first 60 pmol kg‐1infused over a 5‐min period and then 180 pmol kg‐1infused over a 3‐min period. Animals under ganglionic blockade received the same dose as the total infusions in the other series (240 pmol kg‐1) infused over 4 min and a second infusion of 1.2 nmol kg‐1over 5 min.Vhdsodilatory effects were observed in most of thhd tissues tested, but there were marked differences in sensitivity. The most sensitive tissues seemed to be the lacrimal, submandibular and parotid glands, the nictitating membrane, the tongue and the gallbladder. The patterns of sensitivity were similar in all the series, indicating that neither prostaglandins nor autonomic reflexes were involved in the effects.In experiments with animals under ganglionic blockade, an increase in blood pressure, concomitant with an increase in heart rate, was seen 5 min after the infusions ended. Thus, it is likely that the peptide exerts a direct positive chronotropic effect on the feline heart.,