Atherosclerosis 2005 - Recent discoveries and novel hypotheses
Atherosclerosis 2005 - Recent discoveries and novel hypotheses
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DOI：
10.1161/circulationaha.105.577460
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发表时间：
2005-11-22
期刊：
影响因子：
37.8
通讯作者：
Dzau, VJ
中科院分区：
文献类型：
--
作者：
Goldschmidt-Clermont, PJ;Creager, MA;Dzau, VJ
动脉粥样硬化是一种选择性影响动脉的炎症过程，在女性和男性中都非常普遍。动脉粥样硬化的血栓闭塞性并发症，包括中风和心肌梗死，是发病率和死亡率的主要原因。动脉树的衰老是一个遵循自然过程的生物学过程，多种危险因素的联合损伤可以加速动脉树的衰老。生物体固有的修复能力可以抵消动脉的自然时间和风险因素依赖性老化。这种修复过程的失败与动脉粥样硬化炎症和病变形成密切相关。招募和靶向骨髓来源的血管祖细胞，以及可能起源于其他组织的血管祖细胞，这些细胞具有修复血管壁的内在能力，代表了一个有前途的研究和开发领域。这篇综述集中在最近的发现有关血管祖细胞和其他可能影响动脉粥样硬化研究。它强调了令人兴奋的最新发现，证明了血管祖细胞在血管壁的稳态和减轻动脉粥样硬化的重要作用。在动脉粥样硬化的背景下，这篇综述还讨论了这种模式的相关性动脉粥样硬化的药物治疗和衰老的过程。
Atherosclerosis is an inflammatory process that selec-tively affects arteries and is highly prevalent in both women and men. Thrombo-occlusive complications of atherosclerosis, including stroke and myocardial infarction, are major causes of morbidity and mortality. Senescence of the arterial tree is a biological process that follows a natural course that can be accelerated by the combined injury of multiple risk factors. A repair capacity that is intrinsic to the organism can counteract the natural time-and risk factor–dependent obsolescence of arteries. The failure of this repair process is intimately linked to atherosclerotic inflammation and lesion formation. Recruitment and targeting of bone marrow–derived progenitor vascular cells, and probably vascular progenitors originating in other tissues, that have an intrinsic capacity for repair of the vascular wall represent a promising area for research and development. This review focuses on recent discoveries relevant to vascular progenitor cells and others that are likely to influence atherosclerosis research. It highlights the exciting recent findings that demonstrate the vital role of vascular progenitor cells in the homeostasis of the vessel wall and the mitigation of atherosclerosis. In the context of atherosclerosis, this review also discusses the relevance of this paradigm to pharmacological treatment of atherosclerosis and the process of aging.