Intraoperative low-dose dopamine is associated with worse survival in patients with hepatocellular carcinoma: A propensity score matching analysis.
Intraoperative low-dose dopamine is associated with worse survival in patients with hepatocellular carcinoma: A propensity score matching analysis.
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术中低剂量多巴胺与肝细胞癌患者较差的生存率相关：倾向评分匹配分析
DOI：
10.3389/fonc.2022.947172
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发表时间：
2022
影响因子：
4.7
通讯作者：
Chen, Dongtai
中科院分区：
文献类型：
--
作者：
Wang, Yan;Xue, Ruifeng;Xing, Wei;Li, Qiang;Gei, Liba;Yan, Fang;Mai, Dongmei;Zeng, Weian;Yan, Yan;Chen, Dongtai
研究背景多巴胺广泛应用于手术患者。我们评估术中小剂量多巴胺给药与肝细胞癌患者无复发生存率(RFS)和总生存率(OS)的关系。方法研究对象为2008-2010年间连续接受根治性肝切除术的非转移性肝癌患者。采用单因素和多因素Logistic回归分析评价影响RFS和OS的预后因素。生存结果用Kaplan-Meier分析和对数等级检验进行评估。进行一对一倾向得分匹配(PSM)分析，以减少混淆偏差。结果共对805例肝细胞癌患者进行了回顾性分析，其中699例患者术中未接受多巴胺治疗，106例患者术中接受小剂量多巴胺治疗。与未接受多巴胺的患者相比，被分配了低剂量多巴胺的患者的RFS(p=0.009)和OS(p=0.041)更差。多因素回归分析显示，术中应用小剂量多巴胺是RFS的独立不利预测因素(p=0.004)，而不是OS的不利预测因素(p=0.059)。经PSM治疗后，小剂量多巴胺治疗组的RFS(p=0.003)和OS(p=0.002)仍明显较差。当按复发时间分层时，使用低剂量多巴胺的患者在2年内复发的机会显著增加(p=0.007)，但在2年后没有显著增加(p=0.186)。结论术中小剂量多巴胺应用对接受根治性肝切除术的肝癌患者的RFS和OS有负面影响。需要进一步的前瞻性研究来评估小剂量多巴胺对肝细胞癌患者手术结果的影响。
Background Dopamine is widely used in patients during surgery. We evaluated the association between intraoperative low-dose dopamine administration and recurrence-free survival (RFS) and overall survival (OS) in patients with hepatocellular carcinoma (HCC). Methods Consecutive patients with nonmetastatic HCC who underwent radical hepatectomy were enrolled between 2008 and 2010. Univariate and multivariate logistic regression analyses were used to evaluate the prognostic factors for RFS and OS. Survival outcomes were evaluated using Kaplan–Meier analyses with the log-rank test. A one-to-one propensity score matching (PSM) analysis was performed to reduce confounding bias. Results A total of 805 HCC patients, including 699 patients who did not receive dopamine consumption and 106 patients who received low-dose dopamine during the operation, were retrospectively analyzed. The patients who were assigned low-dose dopamine had worse RFS (p = 0.009) and OS (p = 0.041) than those who did not receive dopamine. Multivariate regression analysis showed that the intraoperative administration of low-dose dopamine was an independent unfavorable predictor for RFS (p = 0.004) but not for OS (p = 0.059). After PSM, the low-dose dopamine-treated group still had significantly poorer RFS (p = 0.003) and OS (p = 0.002). When stratified by time of recurrence, patients with low-dose dopamine use had a significantly greater chance of recurrence within 2 years (p = 0.007) but not after 2 years (p = 0.186). Conclusions Intraoperative low-dose dopamine use has a negative impact on RFS and OS in HCC patients who have undergone radical hepatectomy. Further prospective studies are required to assess the effects of low-dose dopamine on surgical outcomes in HCC patients.
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影响因子：
4.1
作者：
Duan JL;Nie RC;Xiang ZC;Chen JW;Deng MH;Liang H;Wang FW;Luo RZ;Xie D;Cai MY
通讯作者：
Cai MY
影响因子：
4.2
作者：
Liu XF;Long HJ;Miao XY;Liu GL;Yao HL
通讯作者：
Yao HL
DOI：
10.1016/s1499-3872(13)60082-x
发表时间：
2013-10-15
影响因子：
3.3
作者：
Lin, Cheng-Xin;Guo, Ya;Lai, Eric C. H.
通讯作者：
Lai, Eric C. H.
影响因子：
9.8
作者：
Nguyen, J.;Luk, K.;Gupta, K.
通讯作者：
Gupta, K.
DOI：
10.1016/j.jamcollsurg.2005.10.005
发表时间：
2006-02-01
影响因子：
5.2
作者：
Shah, SA;Greig, PD;Vollmer, CM
通讯作者：
Vollmer, CM