Monitoring of pH and temperature of neuropathic diabetic and nondiabetic foot ulcers for 12 weeks: An observational study
Monitoring of pH and temperature of neuropathic diabetic and nondiabetic foot ulcers for 12 weeks: An observational study
复制标题
DOI：
10.1111/wrr.12628
复制
发表时间：
2018-03-01
影响因子：
2.9
通讯作者：
O'Loughlin, Aorghus
中科院分区：
文献类型：
--
作者：
Gethin, Georgina;O'Connor, Gerard M.;O'Loughlin, Aorghus
伤口床评估在很大程度上依赖于主观解释，而不求助于客观工具或生物标志物。床旁可靠生物标志物的鉴定将增强评估和最终的临床决策。存在两种潜在的新兴伤口生物标志物：表面pH值和表面温度。迄今为止，其使用的知识主要用于伤口预防、体外研究和单次测量。我们的目的是确定基线和12周时未感染的神经性足溃疡的表面pH值、大小和表面温度。50例患者（68% [n = 34]患有糖尿病）参与了研究。伤口的平均基线pH值为6.95（SD 1.01）;温度为30.91 ℃（SD 3.00）;尺寸为0.82 cm（2）（SD 0.61）。12周后，26%（n = 13）失访，50%（n = 25）愈合。其余患者的平均pH值为6.72（SD 0.54）;体温为30.88摄氏度（SD 2.97），尺寸为0.13厘米（2）（SD 0.13）。我们提供了非感染、神经性糖尿病和非糖尿病足溃疡的pH值和温度的基线值。需要在更大的队列中进行进一步研究，以确定温度和/或pH值是否指示愈合或非愈合状态。
Wound bed assessment is largely reliant on subjective interpretation without recourse to objective tools or biomarkers. The identification of a point of care, reliable biomarker would enhance assessment and ultimately clinical decision making. Two potentially emerging wound biomarkers exist: surface pH and surface temperature. To date, knowledge of their use has been predominantly in wound prevention, in vitro studies and single time measurements. Our objective was to determine surface pH, size, and surface temperature in noninfected, neuropathic foot ulcers at baseline and at 12 weeks. 50 patients (68% [n = 34] had diabetes) participated. Mean baseline pH of wounds was 6.95 (SD 1.01); temperature 30.91 degrees C (SD 3.00); and size 0.82 cm(2) (SD 0.61). After 12 weeks, 26% (n = 13) were lost to follow-up, 50% (n = 25) had healed. Of the remaining patients, mean pH was 6.72 (SD 0.54); temperature 30.88 degrees C (SD 2.97), and size 0.13 cm(2) (SD 0.13). We have provided baseline values for pH and temperature of noninfected, neuropathic diabetic, and nondiabetic foot ulceration. Further studies in a larger cohort are warranted to determine if temperature and or pH are indicative of a healing or nonhealing state.