Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy - A histopathological assessment
Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy - A histopathological assessment
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DOI：
10.1159/000063606
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发表时间：
2002-01-01
影响因子：
2.4
通讯作者：
Englund, E
中科院分区：
文献类型：
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作者：
Haglund, M;Englund, E
为验证阿尔茨海默病（AD）的脑淀粉样血管病（CAA）与白色病变（WML）定量相关的假设，对63例不同程度的阿尔茨海默病脑病（AE）痴呆患者和10例非痴呆对照者的脑进行了沿着检查。在显微镜检查后计算每个患者额极软脑膜中淀粉样蛋白阳性与淀粉样蛋白阴性血管的比例，并根据先前发表的标准对WML的严重程度进行分级。在没有血管性痴呆显著成分的AD病例中，CAA水平与神经病理学诊断和分级的WML程度相关。年龄和AE严重程度与WML均无显著相关性。可能有几个原因，本研究的结果相矛盾的相对维斯早期的调查，不同的染色方法，CAA定量和患者亚组的选择所发挥的作用进行了讨论。版权所有（C）2002 S. Karger AG，巴塞尔。
To test the hypothesis that the cerebral amyloid angiopathy (CAA) of Alzheimer's disease (AD) is quantitatively associated with white matter lesions (WML), the brains of 63 demented patients exhibiting varying degrees of Alzheimer encephalopathy (AE) were examined, along with those of 10 nondemented control cases. The ratio of amyloid-positive to amyloid-negative vessels in the leptomeninges of the frontal pole from each patient was calculated subsequent to microscopical examination, and the severity of WML was graded according to previously published criteria. In AD cases without a significant component of vascular dementia, the level of CAA was found to correlate with the degree of WML diagnosed and graded by neuropathology. Neither age nor severity of AE correlated significantly with WML. There may be several reasons for the conflicting results of this study vis-a-vis earlier investigations; the roles played by different methods of staining, CAA quantitation and patient subgroup selection are also discussed. Copyright (C)2002 S. Karger AG, Basel.