Pestalotiones A-D: Four New Secondary Metabolites from the Plant Endophytic Fungus Pestalotiopsis Theae
Pestalotiones A-D: Four New Secondary Metabolites from the Plant Endophytic Fungus Pestalotiopsis Theae
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Pestalotiones A-D：来自植物内生真菌 Pestalotiopsis Theae 的四种新的次生代谢产物
DOI：
10.3390/molecules25030470
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发表时间：
2020-02-01
期刊：
影响因子：
4.6
通讯作者：
Liu, Ling
中科院分区：
文献类型：
--
作者：
Guo, Longfang;Lin, Jie;Liu, Ling
从植物内生真菌Pestalotopsis theae(N635)的粗提物中分离得到两个新的口山酮衍生物A(1)和B(2)，一个新的二苯酮核苷，一个新的二苯醚，一个新的二苯醚，通过HRESIMS和1D/2D-核磁共振数据确证了新化合物的结构。化合物6对HeLa细胞有较强的细胞毒作用，IC50值为35.2 mU M；化合物9对HeLa细胞和MCF-7细胞有一定的细胞毒作用，IC50分别为60.8和22.6 mU M。此外，化合物1和2还具有清除DPPH自由基的活性，其IC50值分别为54.2和59.2微克/毫升。
Two new xanthone derivatives, pestalotiones A (1) and B (2), one new diphenyl ketone riboside, pestalotione C (7), and one new diphenyl ether, pestalotione D (8), along with five known compounds isosulochrin dehydrate (3), 3,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (4), isosulochrin (5), chloroisosulochrin (6), and pestalotether D (9), were isolated from the crude extract of the plant endophytic fungus Pestalotiopsis theae (N635). The structures of the new compounds were unambiguously deduced by HRESIMS and 1D/2D-NMR spectroscopic data. Compound 6 showed modest cytotoxicity against the HeLa cell line with an IC50 value of 35.2 mu M. Compound 9 also showed cytotoxic to the HeLa and MCF-7 cell lines, with IC50 values of 60.8 and 22.6 mu M, respectively. Additionally, compounds 1 and 2 exhibited antioxidant activity in scavenging DPPH radical with IC50 values of 54.2 and 59.2 mu g/mL, respectively.