In vivo pachymetry in normal eyes of rats, mice and rabbits with the optical low coherence reflectometer
In vivo pachymetry in normal eyes of rats, mice and rabbits with the optical low coherence reflectometer
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DOI：
10.1016/s0042-6989(03)00005-1
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发表时间：
2003-03-01
期刊：
影响因子：
1.8
通讯作者：
Goldblum, D
中科院分区：
文献类型：
--
作者：
Schulz, D;Iliev, ME;Goldblum, D
本研究的目的是使用安装在常规裂隙灯上的非接触式高速光学低相干反射仪(OLCR)来测量活体大鼠、小鼠和兔子的中央角膜厚度(CCT)。对8只雄性Wistar大鼠、8只雄性Balb-c小鼠和8只雄性日本兔的双眼进行了测量。每只眼睛被测量了两次(一次测量包括20次扫描)，计算出了平均值。此外，还使用超声测厚仪测量了兔的CCT。平均CCT为：大鼠：159.08微米(SD+/-14.99um)，小鼠：106.0微米(SD+/-3.45um)，兔：356.11微米(SD+/-14.34um)。通过使用OLCR，我们能够在活体内准确地测量大鼠、小鼠和兔的CCT。这项技术可能会在进一步的屈光、药理学和青光眼研究中被证明是有用的。(C)2003爱思唯尔科学有限公司。保留所有权利。
The aim of this study was to determine the central corneal thickness (CCT) in living rats, mice and rabbits using a non-contact, high-speed optical low coherence reflectometer (OLCR) mounted on a regular slit lamp. Both eyes of eight male Wistar rats, eight male balb-c mice and eight male Japanese rabbits were measured. Each eye was measured twice (one measurement consists of 20 scans), the average calculated. Additionally, CCT was measured in rabbits using an ultrasound pachymeter. The mean CCT was: rats: 159.08 mum (SD+/-14.99 mum), mice: 106.0 mum (SD+/-3.45 mum) and rabbits: 356.11 mum (SD+/-14.34 mum). With the use of OLCR we were able to accurately measure the CCT of rats, mice and rabbits in vivo. This technique may prove useful in further refractive, pharmacological and glaucoma studies. (C) 2003 Elsevier Science Ltd. All rights reserved.