Effect of vitamin D supplementation on depression in elderly patients: A randomized clinical trial
Effect of vitamin D supplementation on depression in elderly patients: A randomized clinical trial
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补充维生素D对老年抑郁症患者的影响：一项随机临床试验
DOI：
10.1016/j.clnu.2018.09.011
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发表时间：
2019-10-01
影响因子：
6.3
通讯作者：
Assarian, Fatemeh
中科院分区：
文献类型：
--
作者：
Alavi, Negin Masoudi;Khademalhoseini, Saeed;Assarian, Fatemeh
背景与目的：老年抑郁症的治疗是一个关键问题。补充维生素D治疗老年抑郁症的效果进行了调查，在这个临床试验方法：这是一个为期8周的随机临床试验，补充维生素D和安慰剂在3个精神科诊所治疗抑郁症。研究样本包括78名60岁以上的老年人，他们患有中度至重度抑郁症。受试者被随机分配接受50，000 U维生素D3珍珠每周8周或安慰剂（每组39名受试者）。主要结局指标包括老年抑郁量表-15（GDS-15）问卷和25-羟基维生素D3 [25（OH）D3]。结果：维生素D组25（OH）D3平均基线浓度为22.57 ± 6.2 ng/ml，安慰剂组为21.2 ± 5.8 ng/ml（p = 0.16）。维生素D增加至43.48 +/- 9.5 ng/ml，安慰剂组为25.9 +/- 15.3 ng/ml。维生素D组的抑郁评分从9.25降至7.48（p = 0.0001），而安慰剂组的抑郁评分无显著增加。多元回归分析显示，维生素D组和研究前抑郁评分是干预后抑郁评分的解释变量，解释率为81.8%。结论：维生素D补充可改善60岁及以上老年人的抑郁评分。(C)2018爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: Treatment of depression in elderly population is a crucial issue. The effect of vitamin D supplementation on treatment of depression in older adults was investigated in this clinical trial.Methods: It was an 8-week, randomized clinical trial of vitamin D supplementation and placebo in the treatment of depression in 3 psychiatric clinics. The study sample included 78 older adults aged over 60 years with moderate to severe depression. Subjects were randomly allocated to receive 50,000 U vitamin D3 pearl weekly for 8 weeks or placebo (39 subjects in each group). Main outcome measures comprised Geriatric Depression Scale-15 (GDS-15) questionnaire and 25-hydroxyvitamin D3 [25(OH)D3]. The analysis utilized Mann Whitney U test, Wilcoxon signed ranks test, chi-square and multiple regression analysis.Results: The mean baseline 25(OH)D3 concentration was 22.57 +/- 6.2 ng/ml in vitamin D group and 21.2 +/- 5.8 ng/ml in placebo group (p = 0.16). The Vitamin D increased to 43.48 +/- 9.5 ng/ml in vitamin D and 25.9 +/- 15.3 ng/ml in placebo group. The depression score decreased from 9.25 to 7.48 in vitamin D group (p = 0.0001), while there was a non-significant increase in depression score in placebo group. The multiple regression analysis showed that the vitamin D group and the score of depression before study were the variables that could explain 81.8% of depression score after intervention.Conclusion: The findings indicated that vitamin D supplementation can improve the depression score in persons aged 60 and over. (C) 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.