Medial temporal MR spectroscopy is related to memory performance in normal adolescent subjects
Medial temporal MR spectroscopy is related to memory performance in normal adolescent subjects
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DOI：
10.1097/01.wnr.0000117645.402776a
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发表时间：
2004-03-22
期刊：
影响因子：
1.7
通讯作者：
Mercader, JM
中科院分区：
文献类型：
--
作者：
Giménez, M;Junqué, C;Mercader, JM
除了研究病理状况外，磁共振波谱还可以提供有关正常受试者脑行为关系的有用信息。最近，有报道N-乙酰天冬氨酸（NAA）值和正常成人的认知功能之间的相关性。我们测试了正常青少年内侧颞叶NAA/胆碱（Cho）比值与记忆表现之间可能的特定关系。内侧颞叶NAA/Cho比值与年龄、性别和一般智力无关，但与几项记忆指标有明显相关性。在回归分析中，两个记忆变量（RAVLT学习和面孔名称识别任务）解释了55.6%的NAA/Cho方差。我们的结论是，NAA值在内侧颞叶相关的记忆能力，但不正常的青少年受试者的整体智力。
In addition to the study of pathological conditions, magnetic resonance spectroscopy can provide useful information about brain-behavior relationships in normal subjects. Recently, there have been reports of correlations between N-acetylaspartate (NAA) values and cognitive functions in normal adults. We tested the possible specific relationship between the NAA/choline (Cho) ratio in the medial temporal lobe and memory performance in normal adolescents. The medial temporal NAA/Cho ratio was unrelated to age, gender and general intelligence but presented a clear correlation with several memory measures. In the regression analysis two memory variables (RAVLT learning and a face-name recognition task) explained 55.6% of NAA/Cho variance. We conclude that NAA values in the medial temporal lobe are related to memory abilities but not to global intelligence in normal adolescent subjects.