Hemodynamic responses of eye movement desensitization and reprocessing in posttraumatic stress disorder
Hemodynamic responses of eye movement desensitization and reprocessing in posttraumatic stress disorder
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DOI：
10.1016/j.neures.2009.08.014
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发表时间：
2009-12-01
影响因子：
2.9
通讯作者：
Kato, Nobumasa
中科院分区：
文献类型：
--
作者：
Ni, Toshiyuki Ohta;Matsuo, Koji;Kato, Nobumasa
眼动脱敏与再加工（EMDR）是治疗创伤后应激障碍（PTSD）的有效心理干预方法。然而，这一过程背后的神经机制仍然未知。13例PTSD患者接受了2-10周的EMDR治疗，我们使用多通道近红外光谱（NIBS）评估了回忆期间有和没有EM的外侧前额叶皮层（PFC）血红蛋白浓度的变化。临床诊断和改善进行了评估，使用临床医生管理PTSD量表。与不使用EM的回忆相比，使用EM的回忆与外侧PFC中氧合血红蛋白浓度（[oxy-Hb]）的显著降低相关。纵向上，当治疗后数据与治疗前数据相比时，回忆期间的[oxy-Hb]显著降低，并且降低的量与临床改善显著相关。我们的研究结果表明，在回忆过程中进行EM减少了外侧PFC的过度活动，这可能是EMDR治疗PTSD疗效的生物学基础的一部分。LAIRS可能是客观评估PTSD心理干预的有用工具（C）2009 Elsevier爱尔兰有限公司和日本神经科学学会版权所有
Eye movement desensitization and reprocessing (EMDR) is an effective psychological intervention for posttraumatic stress disorder (PTSD) Trauma-related recall (Recall) with eye movements (EMs) is thought to reduce distress. However, the neural mechanisms underlying this process remain unknown. Thirteen patients with PTSD received EMDR treatment over the course of 2-10 weeks We assessed the change in hemoglobin concentration in the lateral prefrontal cortex (PFC) during Recall with and without EM using multi-channel near-infrared spectroscopy (NIBS). Clinical diagnosis and improvement were evaluated using the Clinician-Administered PTSD Scale. Recall with EM was associated with a significant decrease in oxygenated hemoglobin concentration ([oxy-Hb]) in the lateral PFC as compared with Recall without EM. Longitudinally, [oxy-Hb] during Recall significantly decreased and the amount of decrease was significantly correlated with clinical improvement when the post-treatment data was compared with that of the pre-treatment. Our results suggest that performing EM during Recall reduces the over-activity of the lateral PFC, which may be part of the biological basis for the efficacy of EMDR in PTSD. LAIRS may be a useful tool for objective assessment of psychological intervention in PTSD (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society All rights reserved