Neurocognitive capabilities modulate the integration of evidence in schizophrenia
Neurocognitive capabilities modulate the integration of evidence in schizophrenia
复制标题
DOI：
10.1016/j.psychres.2014.04.056
复制
发表时间：
2014-09-30
影响因子：
11.3
通讯作者：
Zink, Mathias
中科院分区：
文献类型：
--
作者：
Eifler, Sarah;Rausch, Franziska;Zink, Mathias
以往的研究表明，精神分裂症患者在整合不证实性证据（BADE）时存在认知偏差。这种偏见与妄想有关。到目前为止，还不清楚证据的整合如何与神经认知能力相关联。在目前的研究中，31名精神分裂症患者和29名健康对照者，在年龄，性别，教育和病前语言智力方面相匹配，进行了BADE任务。提出了每三个连续句子的书面情景，逐步减少了情景的模糊性。参与者被要求对四种可能的解释的可解释性进行评级，并根据所提供的句子调整他们的评级。心理测量等级量表和神经心理测试电池。患者在整合证实性证据时表现出偏倚，但在不证实性证据和自由接受信念形成方面没有偏倚。相关性分析显示，证据整合与阳性症状的严重程度没有关联，但与神经认知领域，特别是与处理速度，执行功能，警惕性和工作记忆。总之，精神分裂症患者在证据整合方面存在偏倚。神经认知功能作为一个调节因素，应在进一步的研究中加以考虑。在精神病的早期阶段调查BADE的研究将是必要的，以揭示因果关系。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Previous studies have demonstrated a cognitive bias in the integration of disconfirmatory evidence (BADE) in patients with schizophrenia. This bias has been associated with delusions. So far, it is unclear how the integration of evidence is associated with neurocognitive capabilities. In the current study, 31 patients with schizophrenia and 29 healthy controls, matched on age, gender, education and premorbid verbal intelligence, underwent a BADE task. Written scenarios of three consecutive sentences each were presented, which progressively reduced the ambiguity of situations. Participants were asked to rate the plausibility of four possible interpretations and adjust their ratings in response to the provided sentences. Psychometric rating scales and a neuropsychological test battery were applied. Patients displayed a bias in the integration of confirmatory, but not disconfirmatory evidence and a liberal acceptance of belief formation. Correlation analyses revealed no associations of evidence integration with the severity of positive symptoms, but with neurocognitive domains, especially with processing speed, executive functioning, vigilance and working memory. In conclusion, patients with schizophrenia show a bias in evidence integration. Neurocognitive functioning emerged as a modulatory factor that should be considered in further research. Studies investigating BADE in earlier stages of psychosis will be necessary to reveal causal relationships. (C) 2014 Elsevier Ireland Ltd. All rights reserved.