Odor Identification Deficit as a Predictor of Five-Year Global Cognitive Change: Interactive Effects with Age and ApoE-ε4
Odor Identification Deficit as a Predictor of Five-Year Global Cognitive Change: Interactive Effects with Age and ApoE-ε4
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DOI：
10.1007/s10519-009-9289-5
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发表时间：
2009-09-01
影响因子：
2.6
通讯作者：
Larsson, Maria
中科院分区：
文献类型：
--
作者：
Olofsson, Jonas K.;Ronnlund, Michael;Larsson, Maria
嗅觉障碍存在于常见的神经退行性疾病中，并预示着患有认知障碍的非痴呆个体会转化为痴呆。在认知功能完好的老年人中，关于嗅觉缺陷在预测认知障碍中的作用的证据很少。本研究调查了大型（n = 501）老年人（65-90 岁）人群样本中简易精神状态检查（MMSE）5 年预期下降的预测因素。所有参与者都进行了 ApoE 基因基因分型，评估了健康因素，并且在基线评估时没有痴呆。在排除基线人口和健康因素以及随访时痴呆症的影响后，气味识别能力差加上年龄较大和 ApoE-epsilon 4 等位基因预测了更大的预期全球认知能力下降。这种效果是词汇测试无法产生的。总之，研究结果表明，嗅觉缺陷可以在非痴呆、高龄 epsilon 4 携带者中区分良性和恶性的整体认知发展，这些人患痴呆的风险很高。
Olfactory impairments are present in common neurodegenerative disorders and predict conversion to dementia in non-demented individuals with cognitive impairment. In cognitively intact elderly, evidence is sparse regarding the role of olfactory deficits in predicting cognitive impairment. The present study investigated predictors of 5-year prospective decline in the Mini-Mental State Examination (MMSE) in a large (n = 501), population-based sample of elderly (65-90 years) individuals. All participants were genotyped for the ApoE gene, assessed for health factors, and were non-demented at the baseline assessment. After partialling out the influences of demographic and health-factors at baseline and dementia at follow-up, poor odor identification ability in combination with older age and the ApoE-epsilon 4 allele predicted larger prospective global cognitive decline. This effect could not be produced by a vocabulary test. In sum, the findings suggest that an olfactory deficit can dissociate between benign and malign global cognitive development in non-demented, very old epsilon 4-carriers, who are at high risk of developing dementia.