Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan
Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan
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DOI：
10.1111/j.1525-1438.2006.00754.x
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发表时间：
2007-01-01
影响因子：
4.8
通讯作者：
Terao, T.
中科院分区：
文献类型：
--
作者：
Kobayashi, H.;Sumimoto, K.;Terao, T.
虽然一些研究表明子宫内膜异位症可能会增加患卵巢癌的风险，但在日本没有流行病学研究的数据。我们前瞻性地分析了1985年开始的静冈县范围内子宫内膜异位症和卵巢癌计划的队列研究中的所有卵巢腺瘤病例。为了评估卵巢腺瘤诊断后不同时期卵巢癌的风险，从静冈癌症登记处（SCR）中筛选出一组1985年至1995年间在静冈有临床记录的卵巢腺瘤的6,398名妇女，随访至2002年。卵巢癌的发病率队列成员之间的联系，以确定的SCR使用一个独特的个人识别号码。标准化发病率（SIR）及其95%置信区间（CI）通过使用全州范围的卵巢癌发病率计算，并根据年龄和日历年进行调整。在随访17年的卵巢腺瘤队列中，确定了46例卵巢癌事件，得出卵巢腺瘤患者的卵巢癌风险显著升高（SIR = 8.95，95%CI = 4.12-15.3）。SIR没有随着随访时间的增加而增加。随着年龄的增长，诊断卵巢上皮性腺瘤的风险增加，50岁以上女性的SIR等于13.2（95%CI = 6.90-20.9）。我们的研究结果首次支持了日本静冈的卵巢上皮性腺瘤增加了随后发生卵巢癌的风险的假设。
Although some studies have indicated that endometriosis may increase the risk of developing ovarian cancer, there are no data from epidemiologic studies in Japan. We prospectively analyzed all cases of ovarian endometrioma enrolled in the prefecture-wide Shizuoka Cohort Study on Endometriosis and Ovarian Cancer Programme, which was initiated in 1985. To evaluate the risk of ovarian cancer by time periods subsequent to ovarian endometrioma diagnosis, a cohort of 6,398 women with a clinically documented ovarian endometrioma in Shizuoka between 1985 and 1995 was identified from the Shizuoka Cancer Registry (SCR), with follow-up through 2002. Ovarian cancer incidence among cohort members was ascertained by linkage to the SCR using a unique person-identification number. Standardized incidence ratios (SIR) and their 95% confidence intervals (CI) were computed by a use of prefecture-wide rates of ovarian cancer, adjusted for age and calendar year. During follow-up of up to 17 years of the ovarian endometrioma cohort, 46 incident ovarian cancers were identified, yielding that the ovarian cancer risk was elevated significantly among patients with ovarian endometrioma (SIR = 8.95, 95% CI = 4.12-15.3). The SIR did not increase with increasing follow-up duration. The risk increased with increasing age at ovarian endometrioma diagnosis, with a SIR equal to 13.2 (95% CI = 6.90-20.9) in women above 50 years of age. Our findings for the first time support the hypothesis that ovarian endometrioma increases the subsequent risk of developing ovarian cancer in Shizuoka, Japan.