NONHSAT076754 aids ultrasonography in predicting lymph node metastasis and promotes migration and invasion of papillary thyroid cancer cells.
NONHSAT076754 aids ultrasonography in predicting lymph node metastasis and promotes migration and invasion of papillary thyroid cancer cells.
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NONHSAT076754辅助超声预测淋巴结转移并促进甲状腺乳头状癌细胞的迁移和侵袭
DOI：
10.18632/oncotarget.13725
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发表时间：
2017-01-10
期刊：
影响因子：
--
通讯作者：
Zhan W
中科院分区：
文献类型：
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作者：
Xia S;Wang C;Ni X;Ni Z;Dong Y;Zhan W
淋巴结转移是甲状腺乳头状癌（PTC）的主要挑战。复发的癌性淋巴结需要反复手术，这增加了手术并发症的风险。因此，术前评估LNM是很重要的。超声检查是检查颈部淋巴结转移最方便的方法，但超声检查在PTC病例中识别淋巴结转移的敏感性极低。一系列lncRNA（长链非编码RNA）已被报道为多种肿瘤的候选生物标志物。本研究检测PTC组织中lncRNA NONHSAT 076754的表达，并分析其与PTC患者临床病理及超声特征的相关性。评估了NONHSAT 076754作为辅助诊断生物标志物与超声检查沿着用于鉴别PTC中LNM的价值。此外，证明了NONHSAT 076754在PTC细胞中的生物学功能。我们的研究表明，NONHSAT 076754促进PTC的迁移和侵袭，并作为一个有价值的辅助生物标志物，可以沿着超声检查用于预测宫颈LNM。
Lymph node metastasis (LNM) is the primary challenge in papillary thyroid cancer (PTC). Recurrent cancerous lymph nodes require repeated surgeries, which increases the risk for surgical complications. Thus, the evaluation of LNM before surgery is important. Ultrasonography is the most convenient way to examine cervical LNM, but the sensitivity of ultrasonography in the identification of LNM in cases of PTC is extremely low. A series of lncRNAs (long noncoding RNAs) have been reported as candidate biomarkers in a variety of tumors. This study detected the lncRNA NONHSAT076754 in PTC and analyzed the correlation of NONHSAT076754 with the clinicopathological and ultrasonographic characteristics of patients with PTC. The value of NONHSAT076754 as an auxiliary diagnostic biomarker for use along with ultrasonography in the differentiation of LNM in PTC was assessed. Additionally, the biological function of NONHSAT076754 in PTC cells was demonstrated. Our study indicated that NONHSAT076754 promotes migration and invasiveness of PTC and serves as a valuable auxiliary biomarker that can be used along with ultrasonography in the prediction of cervical LNM.