Maternal levels of prostacyclin, thromboxane, ICAM, and VCAM in normal and preeclamptic pregnancies.
Maternal levels of prostacyclin, thromboxane, ICAM, and VCAM in normal and preeclamptic pregnancies.
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DOI：
10.1111/j.1600-0897.2010.00861.x
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Lewis DF;Canzoneri BJ;Gu Y;Zhao S;Wang Y
评估内皮功能受损和内皮炎症反应是否同时发生在子痫前期妇女中。在正常孕妇（n = 40）和重度子痫前期孕妇（n = 40）入住L&D病房时和分娩后24小时抽取静脉血。提取血浆和血清样品，采用ELISA法检测6-酮类PGF1α和TXB2 （PGI2和TXA2的稳定代谢产物）、细胞间粘附分子（ICAM）和血管细胞粘附分子（VCAM）的含量。数据分析采用Mann-Whitney检验和配对t检验。P < 0.05为差异有统计学意义。与正常妊娠对照组相比，sPE患者入院时和分娩后24小时血浆6-酮PGF1α水平显著降低，P < 0.01。分娩前sPE患者6-酮与PGF1α和TXB2的比值明显低于正常妊娠对照组。正常和sPE患者分娩前后ICAM和VCAM水平无显著差异。与正常妊娠对照组相比，sPE患者母体6-酮- PGF1α水平及6-酮- PGF1α和TXB2的比值降低。相比之下，两组产妇的ICAM和VCAM水平没有差异。这些数据表明，血清ICAM和VCAM水平可能不是子痫前期的敏感炎症生物标志物。
To evaluate whether impaired endothelial function and endothelial inflammatory response occur in parallel in the women with preeclampsia. Venous blood was drawn from normal (n = 40) and severe preeclamptic (sPE) (n = 40) pregnant women when they were admitted to the L&D Unit and 24 hrs after delivery. Plasma and serum samples were extracted and measured for 6-keto PGF1α and TXB2 (stable metabolites of PGI2 and TXA2), and intercellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) by ELISA. Data are analyzed by Mann–Whitney test and paired t-test. The statistical significance is set as P < 0.05. Plasma 6-keto PGF1α levels were significantly reduced at admission and 24 hr after delivery in sPE compared to normal pregnant controls, P < 0.01. The ratio of 6-keto PGF1α and TXB2 was significant less in sPE than that in normal pregnant controls before delivery. There was no significant difference for ICAM and VCAM levels between normal and patients with sPE before and after delivery. Maternal 6-keto PGF1α levels and the ratio of 6-keto PGF1α and TXB2 were decreased in patients with sPE compared to normal pregnant controls. In contrast, maternal ICAM and VCAM levels were not different between the two groups. These data suggest that serum ICAM and VCAM levels may not be sensitive inflammatory biomarkers for preeclampsia.
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DOI：
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发表时间：
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影响因子：
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