Facile synthesis of plasmonic zein nanoshells for imaging-guided photothermal cancer therapy
Facile synthesis of plasmonic zein nanoshells for imaging-guided photothermal cancer therapy
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DOI：
10.1016/j.msec.2018.04.081
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发表时间：
2018-09-01
影响因子：
7.9
通讯作者：
Srivastava, Rohit
中科院分区：
文献类型：
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作者：
Chauhan, Deepak S.;Arunkumar, P.;Srivastava, Rohit
我们演示了利用环境无害的溶剂乙醇，简单、绿色地合成金沉积玉米蛋白纳米壳（AuZNS）。水溶性乙二醇壳聚糖用于玉米蛋白纳米颗粒的稳定和阳离子功能化。在环境条件下，通过非原位方法进行金沉积。AuZNS的尺寸约为100 nm，即使在两倍的治疗剂量下也具有较高的惰性和生物相容性。吸光度调至808 nm，用于成像引导等离子体光热治疗癌症。在25微克的极低治疗剂量和5分钟的生物学上可接受的（500兆瓦）808纳米激光照射下，可以高效地杀死癌细胞，而不考虑其化疗难耐状态。与市售的碘基造影剂相比，AuZNS还表现出更好的x射线衰减。
We demonstrate facile and green synthesis of gold deposited zein nanoshells (AuZNS) using environmental benign solvent ethanol. Water soluble glycol chitosan is used for stabilization as well as for cationic functionalization of zein nanoparticles. Gold deposition is performed via ex-situ method at ambient conditions. AuZNS is of size around 100 nm and shows high inertness and biocompatibility even at double the therapeutic dosage. The absorbance is tuned at 808 nm for imaging-guided plasmonic photothermal therapy of cancer. Highly effective killing of cancer cells irrespective of their chemorefractory status is noticed at a very low therapeutic dosage of 25 ug and 5 min of biologically acceptable (500 mW) 808 nm laser irradiation. AuZNS also exhibit better X-ray attenuation in comparison to the commercially available iodine based contrast agent.