LOCALIZED H-1-NMR SPECTROSCOPY IN PATIENTS WITH CHRONIC HEPATIC-ENCEPHALOPATHY - ANALYSIS OF CHANGES IN CEREBRAL GLUTAMINE, CHOLINE AND INOSITOLS
LOCALIZED H-1-NMR SPECTROSCOPY IN PATIENTS WITH CHRONIC HEPATIC-ENCEPHALOPATHY - ANALYSIS OF CHANGES IN CEREBRAL GLUTAMINE, CHOLINE AND INOSITOLS
复制标题
DOI：
10.1002/nbm.1940040214
复制
发表时间：
1991-04-01
影响因子：
2.9
通讯作者：
ROSS, BD
中科院分区：
文献类型：
--
作者：
KREIS, R;FARROW, N;ROSS, BD
本地化，短回波H-1磁共振波谱从一个地区在顶叶皮层的三名患者患有慢性肝性脑病进行了比较，从健康对照组获得的等效频谱。 发现三个显著差异：谷氨酰胺升高，肌醇降低，胆碱峰强度降低。 脑谷氨酰胺浓度的升高预期是假定的慢性高氨血症的结果。 肌醇峰的50%变化的发现是生理学上意想不到的，迄今未解释。详细描述了数据采集和处理参数。 为了进一步定义光谱异常，这是很容易检测到的未变换的光谱，一个简单的数据分析方案已被使用，包括采集后的低频滤波，线形变换，和差分技术，以澄清光谱变化。
Localized, short echo H-1 magnetic resonance spectra from an area in the parietal cortex of three patients suffering from chronic hepatic encephalopathy are compared with equivalent spectra obtained from healthy control subjects. Three significant differences are found: elevated glutamine, decreased inositol, and decreased choline peak intensities. The elevation of cerebral glutamine concentration is expected as a consequence of the presumed chronic hyperammonemia in this disease. The finding of a 50% change in the inositol peak is physiologically unexpected and so far unaccounted for.Data acquisition and processing parameters are described in detail. To further define spectral abnormalities, which were readily detected in untransformed spectra, a simple data analysis scheme has been used that consists of post-acquisition low-frequency filtering, a lineshape transformation, and a difference technique to clarify spectral changes.