Association of total and calculated free testosterone with androgen deficiency symptoms in patients with type 2 diabetes
Association of total and calculated free testosterone with androgen deficiency symptoms in patients with type 2 diabetes
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DOI：
10.1038/s41443-019-0144-9
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发表时间：
2020-05-01
影响因子：
2.6
通讯作者：
Kejal, Shah
中科院分区：
文献类型：
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作者：
Anupam, Biswas;Shivaprasad, Channabasappa;Kejal, Shah
老年男性雄激素缺乏 (ADAM) 问卷通常用于筛查 2 型糖尿病 (T2DM) 患者的雄激素缺乏症状，但总 (TT) 和游离睾酮 (FT) 水平较低与 ADAM 问卷不同反应之间的关系仍不清楚。本研究的目的是评估 TT 和计算的 FT (cFT) 水平的预测能力，以准确分类 ADAM 状态。我们招募了 70 名对 ADAM 问卷反应呈阳性（A 组）和阴性（B 组）的患者以及 70 名年龄匹配的健康对照者（C 组）（平均年龄 50.5 岁）；使用 Vermeulen 方程估计 TT 的血清水平并估计 cFT。性腺功能减退症定义为存在症状（ADAM 评分阳性）且 TT 水平 < 300 ng/dL 或计算值 (cFT)
The Androgen Deficiency in the Aging Male (ADAM) questionnaire is commonly used to screen type 2 diabetes mellitus (T2DM) patients for androgen deficiency symptoms, but the association of low total (TT) and free testosterone (FT) levels with divergent responses to the ADAM questionnaire remains unclear. The aim of this study was to assess the predictive ability of TT and calculated FT (cFT) levels for accurately classifying ADAM status. We recruited 70 patients each with positive (group A) and negative (group B) responses to the ADAM questionnaire and 70 age-matched healthy controls (group C) (mean age, 50.5 years); serum levels of TT were estimated and cFT were estimated using Vermeulen equation. Hypogonadism was defined as the presence of symptoms (positive ADAM score) along with TT level < 300 ng/dL or calculated (cFT)