Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome.
Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome.
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Pearson 骨髓-胰腺综合征外周血细胞荧光原位杂交分析。
DOI：
10.1067/mpd.2001.116296
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Hiroki Kurahashi
中科院分区：
文献类型：
--
作者：
Itaru Yanagihara;Koji Inui;Keiko Yanagihara;Yong;Junko Tanaka;Keiichi Ozono;S. Okada;Hiroki Kurahashi
我们使用双色荧光原位杂交技术在单细胞水平上估计线粒体DNA缺失，并确定与皮尔逊骨髓胰腺综合征患者淋巴细胞疾病进展的任何相关性。该方法证明了异质性的变化，与血液学改善平行。
We used a dual-color fluorescence in situ hybridization technique to estimate deleted mitochondrial DNA at a single-cell level and determine any correlation with the disease progression in lymphocytes from patients with Pearson marrow-pancreas syndrome. The method demonstrated a shift in heteroplasmy, paralleling the hematologic improvement.