Removal of the E-Olefin Barrier of Humulene Leading to Unnatural Terpenoid-like Skeletons
Removal of the E-Olefin Barrier of Humulene Leading to Unnatural Terpenoid-like Skeletons
复制标题
去除葎草烯的 E-烯烃屏障导致非天然萜类骨架
DOI：
10.1021/acs.orglett.8b03259
复制
发表时间：
2018
期刊：
影响因子：
5.2
通讯作者：
Kikuchi Haruhisa
中科院分区：
文献类型：
--
作者：
Nishimura Takehiro;Kawai Junya;Oshima Yoshiteru;Kikuchi Haruhisa
合成了含有双环[5.4.0]十一烷部分的非天然萜类化合物骨架，以及基于分子内C-C键形成策略的salvialane骨架。这种策略是通过去除蛇麻烯骨架的应变E-烯烃构象而实现的。部分化合物具有PPARα拮抗活性。
An unnatural terpenoid scaffold containing a bicyclo[5.4.0]undecane moiety, as well as a salvialane skeleton based on an intramolecular C–C bond formation strategy were synthesized. Such a strategy was made possible by the removal of strainedE-olefin conformations of the humulene skeleton. Some compounds were identified to show PPARα antagonist activity.