POSITIVE DARWINIAN SELECTION IN EVOLUTION OF PROTEIN INHIBITORS OF SERINE PROTEINASES
POSITIVE DARWINIAN SELECTION IN EVOLUTION OF PROTEIN INHIBITORS OF SERINE PROTEINASES
复制标题
DOI：
10.1101/sqb.1987.052.01.062
复制
发表时间：
1987-01-01
期刊：
影响因子：
--
通讯作者：
WHATLEY, HE
中科院分区：
文献类型：
--
作者：
LASKOWSKI, M;KATO, I;WHATLEY, HE
Kimura（1983）当之无愧地代表了分子进化论者的共识。它断言，绝大多数突变的固定是选择性中性的。自然选择（负达尔文选择）无情地清除了强烈有害的突变。积极的达尔文选择是罕见的。我们同意这一理论，但我们注意到，它处理的是大多数时候发生的事情。我们相信，少数蛋白质是物种特异性的，经常表现出积极的达尔文选择。本文的目的是提供一些证据，丝氨酸蛋白酶的蛋白质抑制剂在其进化中表现出与正达尔文选择有关的特征。尽管”中性理论”现在被广泛相信，但仍有许多”选择论者”反对它，然而，该理论是基于或支持于五个现象学的概括，这五个概括几乎被普遍相信，并且在大多数基础生物化学教科书中明确或含蓄地陈述。正如我们在后面指出的那样，对这些信念的信念是如此强烈，以至于它实际上可能会阻碍可能挑战这种信念的调查。这五个现象学的概括是基于木村（1983），但他们不是直接引用，以使他们尽可能的“理论自由”。我们首先让读者简单地熟悉丝氨酸蛋白酶的蛋白质抑制剂，然后展示它们的进化似乎与中性理论的概括相冲突的情况。
Kimura (1983) deservedly stands as a statement of consensus among molecular evolutionists. It asserts that the overwhelming majority of fixations of mutations are selectively neutral. Selection (negative Darwinian selection) relentlessly weeds out the strongly deleterious mutations. Positive Darwinian selection is rare. We agree with this theory, but we note that it deals with what happens most of the time. We believe that a minority of proteins are species specific and frequently exhibit positive Darwinian selection. The purpose of this paper is to present some evidence that protein inhibitors of serine proteinases exhibit in their evolution characteristics associated with positive Darwinian selection. Although the" neutral theory" is now widely believed, there are still many" selectionists" who oppose it. However, the theory is based on or supported by five phenomenological generalizations, which are almost universally believed and which are explicitly or implicitly stated in most elementary biochemistry texts. As we point out later, the belief in these is so strong that it may in fact serve to thwart investigations that may challenge that belief. The five phenomenological generalizations are based on Kimura (1983), but they are not direct quotes, in order to make them as" theory free" as possible. We first acquaint the reader briefly with protein inhibitors of serine proteinases and then show cases where their evolution seems to conflict with the generalization of the neutral theory.