Preparation of size-controlled (30-100 nm) magnetite nanoparticles for biomedical applications
Preparation of size-controlled (30-100 nm) magnetite nanoparticles for biomedical applications
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DOI：
10.1016/j.jmmm.2006.10.795
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发表时间：
2007-03-01
影响因子：
2.7
通讯作者：
Handa, H.
中科院分区：
文献类型：
--
作者：
Nishio, K.;Ikeda, M.;Handa, H.
合成了几十纳米 (nm) 的尺寸控制磁铁矿纳米颗粒 (MNP)，用于生物医学应用。 X 射线分析和磁性测量表明，单相磁铁矿纳米颗粒是通过在 N-2 脱气 NaOH 水溶液（pH = 12-13）中，在低于 37 摄氏度的不同温度下，用弱氧化剂 NaNO3 氧化氢氧化亚铁（Fe(OH)(2)）来制备的。随着合成温度从 4 摄氏度升高到 37 摄氏度，MNP 的尺寸 (d) 从 102 +/- 减小。 5.6 至 31.7 +/- 4.9 nm，尺寸分布变宽，Delta d/d 从 5.5% 增加至 15%。 MNP 在不使用任何表面活性剂的情况下制备，有利于将功能分子稳定地固定在生物医学应用的表面上。 (c) 2006 Elsevier B.V. 保留所有权利。
Size-controlled magnetite nanoparticles (MNPs) with several dozen nanometers ( nm) were synthesized for biomedical applications. Nanoparticles of single-phase magnetite, as revealed by X-ray analyses and magnetic measurements, were prepared by oxidizing ferrous hydroxide (Fe(OH)(2)) with a weak oxidant NaNO3 in an N-2-deaerated aqueous NaOH solution ( pH = 12-13) at various temperatures below 37 degrees C. As the synthesis temperature increases from 4 to 37 degrees C, the MNPs are decreased in size (d) from 102 +/- 5.6 to 31.7 +/- 4.9 nm and widened in size distribution, Delta d/d increases from 5.5% to 15%. Prepared without using any surfactant, the MNPs are advantageous for immobilizing functional molecules stably on the surfaces for biomedical applications. (c) 2006 Elsevier B.V. All rights reserved.