Nonself-antigens are the cognate Specificities of Foxp3+ regulatory T cells
Nonself-antigens are the cognate Specificities of Foxp3+ regulatory T cells
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DOI：
10.1016/j.immuni.2007.07.019
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发表时间：
2007-09-01
期刊：
影响因子：
32.4
通讯作者：
Lgnatowicz, Leszek
中科院分区：
文献类型：
--
作者：
Pacholczyk, Rafal;Kern, Joanna;Lgnatowicz, Leszek
大多数调节性Foxp 3（+）CD 4（+）T细胞自然产生于胸腺。已经提出，这些细胞上的T细胞受体（TCR）以高或更高的亲和力识别自身-MHC II类-肽复合物，并且它们的特异性反映自身反应性T细胞的特异性。在这里，我们分析了数百个来自调节性或非调节性T细胞的TCR，发现几乎没有证据表明前一个群体更喜欢将自身抗原识别为激动剂。相反，这些细胞识别外来MHC-肽复合物的频率与非调节性T细胞相同。我们的研究结果表明，高亲和力，自身反应性TCR是罕见的所有CD 4（+）T细胞，并表明，选择自我肽是不同的肽，激活相同的调节性T细胞在外周。
The majority of regulatory Foxp3(+)CD4(+) T cells naturally arises in the thymus. It has been proposed that T cell receptors (TCRs) on these cells recognize self-MHC class II-peptide complexes with high or higher affinity and that their specificities mirror specificities of autoreactive T cells. Here, we analyzed hundreds of TCRs derived from regulatory or nonregulatory T cells and found little evidence that the former population preferably recognizes self-antigens as agonists. Instead, these cells recognized foreign MHC-peptide complexes as often as nonregulatory T cells. Our results show that high-affinity, autoreactive TCRs are rare on all CD4(+) T cells and suggest that selecting self-peptide is different from the peptide that activates the same regulatory T cells in the periphery.