Estrogen‐replacement therapy after breast cancer risks versus benefits-猫眼课题宝

乳腺癌后雌激素替代疗法的风险与益处

DOI：

发表时间：

1993

期刊：

Cancer

影响因子：

6.2

通讯作者：

中科院分区：

医学1区

文献类型：

作者：

D. Marchant

在当前老龄化社会，超过3000万女性绝经后平均寿命为28岁。冠心病是老年女性死亡的主要原因，而骨质疏松症每年估计会导致 150 万例骨折。各种研究表明绝经后雌激素替代疗法可以降低与这些疾病相关的发病率和死亡率。根据多项“自然实验”的结果，有人建议，对于乳腺癌已成功治疗的更年期女性，应考虑进行雌激素替代疗法。回顾了雌激素替代疗法的益处和风险，并提出了管理和未来研究的建议。

In the current aging society, more than 30 million women have an average postmenopausal life expectancy of 28 years. Coronary heart disease is the leading cause of death in older women, and osteoporosis results in an estimated 1.5 million fractures per year. Various studies have suggested that postmenopausal estrogen‐replacement therapy could reduce the morbidity and mortality associated with these conditions. Based on the results of several “natural experiments,” it was proposed that estrogen‐replacement therapy should be considered for menopausal women who have been treated successfully for breast cancer. The benefits and risks of estrogen‐replacement therapy are reviewed, and recommendations for management and future research are suggested.