Propagating motor cortical patterns of excitability are ubiquitous across human and non-human primate movement initiation.
Propagating motor cortical patterns of excitability are ubiquitous across human and non-human primate movement initiation.
复制标题
运动皮质的兴奋性传播模式在人类和非人类灵长类动物运动启动过程中普遍存在。
DOI：
10.1016/j.isci.2023.106518
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发表时间：
2023
期刊：
影响因子：
5.8
通讯作者：
Hatsopoulos,NicholasG
中科院分区：
文献类型：
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作者：
Balasubramanian,Karthikeyan;Arce-McShane,FritzieI;Dekleva,BrianM;Collinger,JenniferL;Hatsopoulos,NicholasG
在非人类灵长类动物中，在到达运动开始之前，兴奋性的时空模式在初级运动皮层传播。如果这种模式是自主运动启动的必要组成部分，那么它应该存在于各种运动任务、末端效应器甚至物种中。在这里，我们表明，传播模式的兴奋性发生在非人类灵长类动物的精密握力和舌头伸出，甚至在人类参与者的等距手腕伸展启动。在所有的任务中，传播的方向在整个皮质片双峰分布在审判模式取向大致相反。传播速度是单峰分布的任务和物种之间的平均速度相似。此外，传播方向和速度没有系统地改变与任何行为的措施，除了响应时间，表明这种传播模式是不变的运动学或动力学的细节，可能是一个通用的运动启动信号。
A spatiotemporal pattern of excitability propagates across the primary motor cortex prior to the onset of a reaching movement in non-human primates. If this pattern is a necessary component of voluntary movement initiation, it should be present across a variety of motor tasks, end-effectors, and even species. Here, we show that propagating patterns of excitability occur during the initiation of precision grip force and tongue protrusion in non-human primates, and even isometric wrist extension in a human participant. In all tasks, the directions of propagation across the cortical sheet were bimodally distributed across trials with modes oriented roughly opposite to one another. Propagation speed was unimodally distributed with similar mean speeds across tasks and species. Additionally, propagation direction and speed did not vary systematically with any behavioral measures except response times indicating that this propagating pattern is invariant to kinematic or kinetic details and may be a generic movement initiation signal.