CAR T-cell therapy for glioblastoma: ready for the next round of clinical testing?
CAR T-cell therapy for glioblastoma: ready for the next round of clinical testing?
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DOI：
10.1080/14737140.2018.1451749
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发表时间：
2018-05
影响因子：
3.3
通讯作者：
Krenciute G
中科院分区：
文献类型：
--
作者：
Prinzing BL;Gottschalk SM;Krenciute G
The outcome for patients with glioblastoma (GBM) remains poor, and there is an urgent need to develop novel therapeutic approaches. T cells genetically modified with chimeric antigen receptor (CARs) hold the promise to improve outcomes since they recognize and kill cells through different mechanisms than conventional therapeutics. This article reviews CAR design, tumor associated antigens expressed by GBMs that can be targeted with CAR T cells, preclinical and clinical studies conducted with CAR T cells, and genetic approaches to enhance their effector function. While preclinical studies have highlighted the potent anti-GBM activity of CAR T cells, the initial foray of CAR T-cell therapies into the clinic resulted only in limited benefits for GBM patients. Additional genetic modification of CAR T cells has resulted in a significant increase in their anti-GBM activity in preclinical models. We are optimistic that clinical testing of these enhanced CAR T cells will be safe and result in improved anti-glioma activity in GBM patients.
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影响因子：
17.1
作者：
Brentjens RJ;Davila ML;Riviere I;Park J;Wang X;Cowell LG;Bartido S;Stefanski J;Taylor C;Olszewska M;Borquez-Ojeda O;Qu J;Wasielewska T;He Q;Bernal Y;Rijo IV;Hedvat C;Kobos R;Curran K;Steinherz P;Jurcic J;Rosenblat T;Maslak P;Frattini M;Sadelain M
通讯作者：
Sadelain M
影响因子：
20.3
作者：
Bollard, CM;Rössig, C;Rooney, CM
通讯作者：
Rooney, CM
影响因子：
4.4
作者：
Ankri, Chen;Shamalov, Katerina;Cohen, Cyrille J.
通讯作者：
Cohen, Cyrille J.
DOI：
10.1158/1078-0432.ccr-09-1322
发表时间：
2010-01-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Ahmed N;Salsman VS;Kew Y;Shaffer D;Powell S;Zhang YJ;Grossman RG;Heslop HE;Gottschalk S
通讯作者：
Gottschalk S
影响因子：
11.2
作者：
Baker GJ;Chockley P;Yadav VN;Doherty R;Ritt M;Sivaramakrishnan S;Castro MG;Lowenstein PR
通讯作者：
Lowenstein PR