Maternal and offspring toxicity but few sexually dimorphic behavioral alterations result from nonylphenol exposure
Maternal and offspring toxicity but few sexually dimorphic behavioral alterations result from nonylphenol exposure
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DOI：
10.1016/s0892-0362(00)00071-4
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发表时间：
2000-07-01
影响因子：
2.9
通讯作者：
Newbold, RR
中科院分区：
文献类型：
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作者：
Ferguson, SA;Flynn, KM;Newbold, RR
壬基酚聚氧乙烯酯用于生产表面活性剂，并在许多制造物质中发现，对壬基酚（NP）是一种可疑的内分泌干扰物，表现出雌激素样活性，可能导致发育暴露的改变。为了评估这种影响，怀孕的Sprague-Dawley大鼠在妊娠日（GD）开始食用含有0 （n = 11）、25 （n = 10）、500 （n = 10）或2000 (n = 9) ppm NP的饮食。在出生后第21天（PND），后代继续使用相同的母亲饮食直到PND 77，并评估行为改变（PND 22-24、43-45、64-66时的露天活动，PND 35时的玩耍行为，PND 63-77时的跑步轮活动，PND 69-75时的调味溶液摄入量）。在怀孕和哺乳期，浓度为25ppm、500ppm和2000ppm组的雄性熊猫消耗的食物减少了9%到25%，这与浓度为2000ppm组的雄性熊猫在第1至21天体重增加减少了17%有关，尽管这种影响在统计上并不显著。妊娠期、出生体重、活仔的性别比和每窝活仔或死仔的数量在处理组之间没有差异。小鼠子代体重和摄食量均下降。，从PNP 28开始的000ppm组；然而，饲料厌恶的影响不能消除。后代的行为评估表明，在PNDs 22-24、43-45和65-67的开阔场地活动中，以及在PNDs 63-75的跑步轮活动中，没有一致的np相关影响。PND 35的玩耍行为和PND 69-71的0.3%糖精溶液的摄入量在各治疗组之间没有差异。然而，在PNDs 73-75中，2000 -ppm组的后代摄入3%钠味溶液的量显著增加，在同一时间内摄入普通水的量也显著增加。这些结果表明，发育性NP治疗导致母体和后代毒性，其证据是食物摄入量减少和体重增加。然而，行为改变只有在钠溶液摄入量增加时才明显。(C) 2000 Elsevier Science Inc.；版权所有。
Nonylphenol ethoxylates are used in the production of surfactants and are found in numerous manufactured substances, para-Nonylphenol (NP) is a suspected endocrine disrupter, exhibiting estrogen-like activity and might cause alterations with developmental exposure. To evaluate such effects, pregnant Sprague-Dawley rats consumed diets containing 0 (n = 11), 25 (n = 10), 500 (n = 10), or 2,000 (n = 9) ppm NP beginning on gestational day (GD) 7. At postnatal day (PND) 21, offspring continued on the same maternal diets until PND 77 and were evaluated for behavioral alterations (open-field activity at PNDs 22-24, 43-45, 64-66, play behavior at PND 35, running wheel activity at PND 63-77, flavored solution intake at PND 69-75). During pregnancy and lactation, darns in the 25-, 500-, and 2,000-ppm groups consumed 9 to 25% less food, which was associated with a 17% less weight gain during GDs 1 to 21 in dams of the 2,000-ppm group, although this effect was not statistically significant. Gestation duration, birth weight, sex ratio of live pups, and number of live or dead pups per litter did not differ between treatment groups. Offspring body weight and food consumption were decreased in the ?,000ppm group beginning at PNP 28; however, an effect of feed aversion could not be eliminated. Behavioral assessments of offspring indicated no consistent NP-related effects in open-field activity at PNDs 22-24, 43-45, and 65-67 nor in running wheel activity at PNDs 63-75. Play behavior at PND 35 and intake of a 0.3% saccharin-flavored solution at PNDs 69-71 did not differ with respect to treatment groups. However, intake of a 3% sodium-flavored solution at PNDs 73-75 was significantly increased in offspring of the 2,000-ppm group and intake of regular water during this same time was also significantly increased. These results indicate that developmental NP treatment results in maternal and offspring toxicity as evidenced by decreased food intake and weight gain. However, behavioral alterations were evident only in increased intake of a sodium solution. (C) 2000 Elsevier Science Inc. All rights reserved.