Social reasoning, emotion and empathy in frontotemporal dementia
Social reasoning, emotion and empathy in frontotemporal dementia
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DOI：
10.1016/j.neuropsychologia.2005.08.009
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发表时间：
2006-01-01
期刊：
影响因子：
2.6
通讯作者：
Hodges, JR
中科院分区：
文献类型：
--
作者：
Lough, S;Kipps, CM;Hodges, JR
前言：社会认知是人类互动的关键，在额叶变异型额颞叶痴呆(FvFTD)中，社会认知明显受损。方法：对fvFTD患者(n=18)和对照组(n=13)进行测试，使用设计的任务评估他们的心理理论(Tom)、道德推理、情绪识别和执行功能。照顾者记录了与患病前功能相比的共情变化。结果：我们发现，与对照组相比，fvFTD患者的心智能力(TOM)明显受损，这在卡通测试中很明显，但在基于故事的TOM任务中没有。对社会规则的了解是完好无损的，但道德推理是有缺陷的，部分原因是无法适当地评估道德和常规违规行为的严重性。在这一组中，执行功能受损，道德推理的各个方面都受到了损害，但心理理论的表现与此无关。在fvFTD中，情绪识别在全球范围内都受到了损害，但在愤怒和厌恶方面尤其如此，这可能部分解释了这些患者在识别社交违规行为方面的困难。结论：fvFTD患者的社会推理能力似乎以多种方式受到干扰，这一发现为理解和进一步研究fvFTD的异常行为提供了基础。根据社会认知研究中的神经影像结果和fvFTD的病理部位对结果进行了讨论。(C)2005爱思唯尔有限公司。保留所有权利。
Introduction: Social cognition is crucial for human interaction, and is markedly impaired in the frontal variant of frontotemporal dementia (fvFTD). The relationship of various aspects of social functioning, however, remains controversial in this group.Methods: Patients with fvFTD (n = 18), and matched controls (n = 13), were tested using tasks designed to assess their Theory of Mind (ToM), moral reasoning, emotion recognition and executive function. Caregivers documented changes in empathy compared to premorbid functioning.Results: We found marked impairments in the abilities of fvFTD patients, relative to controls, in ability to mentalise (ToM), which was evident on a cartoon test, but not on a story-based ToM task. Knowledge of social rules was intact, but moral reasoning was defective, and was due, in part, to an inability to rate the seriousness of moral and conventional transgressions appropriately. Executive function was impaired in this group, and compromised aspects of moral reasoning, but ToM performance was independent of this. Emotion recognition was globally impaired in fvFTD, but was particularly so for anger and disgust which may partly explain the difficulty these patients have with identifying social violations. Empathy, as rated by carers, was also shown to be abnormal.Conclusion: It appears that social reasoning is disrupted in a number of ways in fvFTD, and the findings provide a basis for the understanding and further study of abnormal behaviour in this disease. The results are discussed in light of neuroimaging findings in studies of social cognition and the locus of pathology in fvFTD. (c) 2005 Elsevier Ltd. All rights reserved.