OCCUPATION AND CANCER OF THE ORAL CAVITY OR OROPHARYNX IN TURIN, ITALY
OCCUPATION AND CANCER OF THE ORAL CAVITY OR OROPHARYNX IN TURIN, ITALY
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DOI：
10.5271/sjweh.1706
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发表时间：
1991-08-01
影响因子：
6.3
通讯作者：
TERRACINI, B
中科院分区：
文献类型：
--
作者：
MERLETTI, F;BOFFETTA, P;TERRACINI, B
在一项以人群为基础的病例参照研究中，对86名口腔癌或口咽癌男性和373名参照者的职业经历进行了分析，涉及41个职业和40个行业的就业情况，以及通过工作暴露矩阵估计的16种化学品的暴露情况。风险较高的职业和行业包括机械操作员（比值比[OR] 2.0； 95%可信区间[95% CI] 1.0-4.0）、水管工（比值比[OR] 5.0, 95%可信区间[95% CI] 1.2-21.5）、建筑业（比值比[OR] 2.5； 95%可信区间[95% CI] 1.3-4.5）、纺织业（比值比[OR] 2.5； 95%可信区间[95% CI] 0.6-4.6）和电力生产（比值比[OR] 2.8； 95%可信区间[95% CI] 0.7-12.1）。所有OR估计值都根据年龄、教育程度、出生地区、吸烟和饮酒进行了调整。甲醛暴露与口腔癌之间存在关联（任何暴露的OR值为1.6,95% CI为0.9-2.8；可能或明确暴露的OR值为1.8,95% CI为0.6-5.5）。基质中没有其他化学物质显示出任何风险模式。甲醛暴露与口腔癌或口咽癌之间的关联的证据被本研究的结果加强。
In a population-based case-referent study, the occupational experience of 86 men with oral or oropharyngeal cancer and 373 referents was analyzed with respect to employment in 41 occupations and 40 industries, as well as to exposure to 16 chemicals, as estimated via a job-exposure matrix. Among the occupations and industries at higher risk were machinery operator (odds ratio [OR] 2.0; 95 % confidence interval [95 % CI] 1.0-4.0), plumber (OR 5.0, 95 % CI 1.2-21.5), building industry (OR 2.5; 95 % CI 1.3-4.5), textile industry (OR 2.5; 95 % CI 0.6-4.6), and electricity production (OR 2.8; 95 % CI 0.7-12.1). All the OR estimates were adjusted for age, education, area of birth, tobacco smoking, and alcohol consumption. An association between formaldehyde exposure and oral cancer was suggested (OR for any exposure 1.6, 95 % CI 0.9-2.8; OR for probable or definite exposure 1.8, 95 % CI 0.6-5.5). No other chemical included in the matrix showed any risk pattern. The evidence of an association between formaldehyde exposure and oral or oropharyngeal cancer is strengthened by the results of this study.