Acupuncture for migraine prophylaxis: a randomized controlled trial
Acupuncture for migraine prophylaxis: a randomized controlled trial
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DOI：
10.1503/cmaj.110551
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发表时间：
2012-03-06
影响因子：
14.6
通讯作者：
Liang, Fan-rong
中科院分区：
文献类型：
--
作者：
Li, Ying;Zheng, Hui;Liang, Fan-rong
背景：针灸是治疗偏头痛的常用方法。我们评估了针刺偏头痛特定穴位的疗效，并与其他穴位和假针灸进行了比较。方法：我们进行了多中心、单盲随机对照试验。总共，480名偏头痛患者被随机分为四组(邵阳特效针刺组、邵阳非特效组、阳明特效组或假针刺组[对照组])。在四周的时间里，所有组都接受了20次治疗，其中包括电刺激。主要结果是随机分组后5、8周内发生偏头痛的天数。我们的次要结果包括偏头痛发作的频率、偏头痛强度和偏头痛特有的生活质量。结果：与对照组患者相比，针刺组患者在5-8周内偏头痛的天数减少，但两种治疗方法之间的差异无统计学意义(p>；0.05)。13~16周各针刺组偏头痛天数均较对照组明显减少(邵阳针灸VS对照组：差值1.06[95%可信区间1.77~0.51P=0.003；邵阳非特异针刺VS对照组差值1.22[95%CL1.92至0.52P&t；0.001；阳明针刺VS对照组差值0.91[95%CL1.61至0.21]，P=0.011]。我们发现，与对照组相比，三个针刺组的几乎所有次要结果都有显著的好处，但在临床上没有相关性。我们没有发现三个针刺组之间的相关差异。解释：与假针灸相比，针灸试验在预防偏头痛方面的临床效果似乎很小。
Background: Acupuncture is commonly used to treat migraine. We assessed the efficacy of acupuncture at migraine-specific acupuncture points compared with other acupuncture points and sham acupuncture.Methods: We performed a multicentre, singleblind randomized controlled trial. In total, 480 patients with migraine were randomly assigned to one of four groups (Shaoyangspecific acupuncture, Shaoyang-nonspecific acupuncture, Yangming-specific acupuncture or sham acupuncture [control]). All groups received 20 treatments, which included electrical stimulation, over a period of four weeks. The primary outcome was the number of days with a migraine experienced during weeks 5 8 after randomization. Our secondary outcomes included the frequency of migraine attack, migraine intensity and migrainespecific quality of life.Results: Compared with patients in the control group, patients in the acupuncture groups reported fewer days with a migraine during weeks 5-8, however the differences between treatments were not significant (p > 0.05). There was a significant reduction in the number of days with a migraine during weeks 13-16 in all acupuncture groups compared with control (Shaoyang-specific acupuncture v. control: difference 1.06 [95% confidence interval (Cl) 1.77 to 0.51, p = 0.003; Shaoyang-nonspecific acupuncture v. control: difference 1.22 [95% Cl 1.92 to 0.52], p < 0.001; Yangming-specific acupuncture v. control: difference 0.91 [95% Cl 1.61 to 0.21], p = 0.011). We found that there was a significant, but not clinically relevant, benefit for almost all secondary outcomes in the three acupuncture groups compared with the control group. We found no relevant differences between the three acupuncture groups. Interpretation: Acupuncture tested appeared to have a clinically minor effect on migraine prophylaxis compared with sham acupuncture.