Human serum catalase decreases endothelial cell injury from hydrogen peroxide.
Human serum catalase decreases endothelial cell injury from hydrogen peroxide.
复制标题
人血清过氧化氢酶可减少过氧化氢造成的内皮细胞损伤。
DOI：
10.1152/jappl.1991.71.5.1903
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Repine,JE
中科院分区：
文献类型：
--
作者：
Leff,JA;Oppegard,MA;Terada,LS;McCarty,EC;Repine,JE
Serum from normal human subjects contained variable amounts of catalase activity, which was inhibitable by heat, azide, trichloroacetic acid (TCA), or aminotriazole treatment. Serum also decreased hydrogen peroxide (H2O2) concentrations in vitro and H2O2-mediated injury to cultured endothelial cells. By comparison, heat-, azide-, TCA-, or aminotriazole-treated serum neither decreased H2O2 concentrations in vitro nor reduced H2O2-mediated damage to endothelial cells. We conclude that serum catalase activity can alter H2O2-dependent reactions. We speculate that variations in serum catalase activity may alter individual susceptibility to oxidant-mediated vascular disease or be a factor when added to test systems in vitro.
