A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone
A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone
复制标题
微波加热组织工程骨修复新型股骨头坏死动物模型
DOI：
10.1007/s00264-008-0672-2
复制
发表时间：
2009-04-01
影响因子：
2.7
通讯作者：
Wei, Lei
中科院分区：
文献类型：
--
作者：
Li, Yanlin;Han, Rui;Wei, Lei
本研究的目的是通过微波加热诱导股骨头坏死（ONFH）动物模型，并应用组织工程骨进行修复。用微波对84只家兔双侧股骨头进行不同温度的加热。应用组织工程骨修复微波诱导的股骨头坏死。采用X线片和组织学检查对结果进行评价。55°C加热10 min的股骨头X线片显示低密度和囊变，4周和8周时组织学上骨坏死和修复同时发生，12周时69%的股骨头塌陷。组织工程骨修复骨坏死的能力接近于自体松质骨移植。微波加热可建立新的ONFH动物模型，组织工程技术将为ONFH的治疗提供有效的手段。
The objective of this research was to induce a new animal model of osteonecrosis of the femoral head (ONFH) by microwave heating and then repair with tissue engineered bone. The bilateral femoral heads of 84 rabbits were heated by microwave at various temperatures. Tissue engineered bone was used to repair the osteonecrosis of femoral heads induced by microwave heating. The roentgenographic and histological examinations were used to evaluate the results. The femoral heads heated at 55°C for ten minutes showed low density and cystic changes in X-ray photographs, osteonecrosis and repair occurred simultaneously in histology at four and eight weeks, and 69% femoral heads collapsed at 12 weeks. The ability of tissue engineered bone to repair the osteonecrosis was close to that of cancellous bone autograft. The new animal model of ONFH could be induced by microwave heating, and the tissue engineering technique will provide an effective treatment.