Expansion of hematopoietic stem cells for transplantation: current perspectives.
Expansion of hematopoietic stem cells for transplantation: current perspectives.
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DOI：
10.1186/2162-3619-1-12
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发表时间：
2012-05-14
影响因子：
10.9
通讯作者：
Aguila JR
中科院分区：
文献类型：
--
作者：
Schuster JA;Stupnikov MR;Ma G;Liao W;Lai R;Ma Y;Aguila JR
造血干细胞（HSCs）是一种罕见的细胞，具有独特的自我更新和分化为所有造血谱系细胞的能力。造血干细胞的扩增一直是开发骨髓移植和许多血液疾病的先进细胞疗法的重要目标。在过去的几十年中，已经有许多尝试使用已知调节HSC的纯化的生长因子体外扩增HSC。然而，这些尝试在临床应用中取得了有限的成功。HSC扩增领域的新发展加上基因治疗和干细胞移植应鼓励许多疾病，包括血液病，免疫缺陷和遗传性疾病的有吸引力的治疗方案的进展。
Hematopoietic stem cells (HSCs) are rare cells that have the unique ability to self-renew and differentiate into cells of all hematopoietic lineages. The expansion of HSCs has remained an important goal to develop advanced cell therapies for bone marrow transplantation and many blood disorders. Over the last several decades, there have been numerous attempts to expand HSCs in vitro using purified growth factors that are known to regulate HSCs. However, these attempts have been met with limited success for clinical applications. New developments in the HSC expansion field coupled with gene therapy and stem cell transplant should encourage progression in attractive treatment options for many disorders including hematologic conditions, immunodeficiencies, and genetic disorders.