Non-genomic actions of progesterone in the normal and neoplastic mammalian ovary
Non-genomic actions of progesterone in the normal and neoplastic mammalian ovary
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DOI：
10.1055/s-2007-973432
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发表时间：
2007-05-01
影响因子：
2.7
通讯作者：
Peluso, John J.
中科院分区：
文献类型：
--
作者：
Peluso, John J.
本文综述了孕酮调节正常和肿瘤哺乳动物卵巢功能的非基因组或膜启动作用的最新研究结果。本文综述了三种受体：经典的孕激素受体、最初从正常卵巢克隆的膜孕酮受体(MPRα、β和γ)，以及孕酮结合蛋白，称为孕酮受体膜组分-1(PGRMC1)。具体地说，这些受体的结构被比较，并与它们激活不同信号转导途径的能力有关。然后讨论了P4对卵巢表面上皮细胞衍生的颗粒细胞、黄体细胞、卵巢表面上皮细胞和卵巢癌功能的生物学作用及其与这些受体表达的关系。只要有可能，涉及人类细胞和组织的研究都会被提出，尽管来自其他哺乳动物物种的数据被用来补充人类研究，以提供关于这一复杂和快速发展的黄体酮膜启动活动区域的更完整的图景。
This review summarizes recent findings on the non-genomic or membrane-initiated actions of progesterone that regulate the function of the normal and neoplastic mammalian ovary. This review focuses on three receptors: the classic progesterone receptor, the membrane progesterone receptors (MPR alpha, beta, and gamma) that were initially cloned from seatrout ovaries, and a progesterone binding protein referred to as progesterone receptor membrane component-1 (PGRMC1). Specifically, the structure of each of these receptors is compared and related to their capacity to activate various signal transduction pathways. Then the biological effects of P4 on the function of granulosa cells, luteal cells, ovarian surface epithelial cells, and ovarian cancers that are derived from the ovarian surface epithelial cells are discussed in relationship to the expression of each of these receptors. Whenever possible, studies involving human cells and tissues are presented, although data from other mammalian species are used to supplement the human studies to provide a more complete picture of this complex and rapidly developing area of membrane-initiated actions of progesterone.