PDT Light Fluence Phantom Modeling of the Human Pleural Cavity: A Proof-of-Concept Pre-Clinical Study.
PDT Light Fluence Phantom Modeling of the Human Pleural Cavity: A Proof-of-Concept Pre-Clinical Study.
复制标题
人体胸膜腔 PDT 光通量模型模型：概念验证临床前研究。
DOI：
10.1117/12.2654485
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Zhu,TimothyC
中科院分区：
文献类型：
--
作者：
Sourvanos,Dennis;Sun,Hongjing;Cengel,KeithA;Fiorellini,JosephP;Zhu,TimothyC
我们已经开发了一种新的扫描协议，使用手持三维（3D）表面采集设备的真人大小的人体模型。该技术将被用于开发恶性间皮瘤光动力学治疗（PDT）过程中胸膜腔内空间的光通量建模。胸腔体模的外部由类似于普通人体解剖结构（胸膜腔空间）的硬化合成聚合物预制而成，内部保持中空，没有任何特征。两个表面都用非反射粘合剂纸分层以产生不均匀的表面形貌。这些表面特征在随机X-Y-Z坐标中建立，尺寸范围为1- 15 mm。该方案使用手持式枕部扫描仪和MEDIT i700。Occipital器械和MEDIT器械分别需要24 cm和1 cm的最小扫描仪至表面距离。成功地扫描了体模模型的外部和内部方面，获取实际值的数字测量值并转换为数字图像文件。通过枕骨器械获取初始表面渲染，并使用专有软件引导MEDIT器械填充空隙区域。该协议伴随着一个可视化工具，允许在2D和3D的表面采集的实时检查。该扫描方案可用于扫描胸膜腔，以在PDT期间实时指导光通量建模，这将扩展到正在进行的临床试验。
We have developed a novel scanning protocol for a life-sized human phantom model using handheld threedimensional (3D) surface acquisition devices. This technology will be utilized to develop light fluence modeling of the internal pleural cavity space during Photodynamic Therapy (PDT) of malignant mesothelioma. The external aspect of the chest cavity phantom was prefabricated of a hardened synthetic polymer resembling ordinary human anatomy (pleural cavity space) and the internal aspect remained hollow without any characterizations. Both surfaces were layered with non-reflective adhesive paper to create non-uniformed surface topographies. These surface characteristics were established in randomized X-Y-Z coordinates ranging in dimensions from 1-15mm. This protocol utilized the handheld Occipital Scanner and the MEDIT i700. The Occipital device required a minimum scanner-to-surface distance of 24cm and the MEDIT device 1cm respectively. The external and internal aspects of the phantom model were successfully scanned acquiring digital measurements in actual value and converted into a digital image file. The initial surface rendering was acquired by the Occipital device and applied with proprietary software to guide the MEDIT device to fill voided areas. This protocol is accompanied by a visualization tool that allows for real-time inspection of surface acquisition in 2D and 3D. This scanning protocol can be utilized to scan the pleural cavity for real-time guidance for light fluence modeling during PDT, which will be expanded to ongoing clinical trials.