MOLECULAR-GENETIC ANALYSIS OF AZOLE ANTIFUNGAL MODE OF ACTION
MOLECULAR-GENETIC ANALYSIS OF AZOLE ANTIFUNGAL MODE OF ACTION
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DOI：
10.1042/bst0211034
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发表时间：
1993-11-01
影响因子：
3.9
通讯作者：
KELLY, DE
中科院分区：
文献类型：
--
作者：
KELLY, SL;ARNOLDI, A;KELLY, DE
唑类抗真菌化合物通过抑制甾醇14 α-脱甲基酶（一种参与麦角甾醇生物合成的细胞色素P-450）起作用[11]。它们在农业中的应用是广泛的，在临床应用中，它们是一个重要的治疗进展[Z]。然而，唑类耐药和耐药的许多细节仍不清楚。耐药性在该领域正在增加，并且有越来越多的唑类药物治疗失败的报道（C。A.希区柯克，这个座谈会; D。W. Hollomon，this colloquium）.许多研究关注唑效应和甾醇谱的生物化学相关性。的
Azole antifungal compounds act by inhibition of sterol 14a-demethylase, a cytochrome P-450 involved in ergosterol biosynthesis [11. Their use in agriculture is widespread and in clinical application they are a significant therapeutic development [Z]. However, many of the details of azole tolerance and resistance are still unclear. Resistance is increasing in the field and there are increasing reports of therapeutic failure following azole treatment (C. A. Hitchcock, this colloquium; D. W. Hollomon, this colloquium). Much research concerns biochemical correlates of azole effect and sterol profiles. The