Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells
Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells
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DOI：
10.1016/j.lungcan.2011.06.002
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发表时间：
2012-01-01
期刊：
影响因子：
5.3
通讯作者：
Ueoka, Hiroshi
中科院分区：
文献类型：
--
作者：
Tao, Hiroyuki;Mimura, Yusuke;Ueoka, Hiroshi
转录因子FOXP3的表达表征了参与维持免疫自身耐受和免疫稳态的调节性T细胞（TCLs）。在几种癌症中，TdR的肿瘤内积累与不良预后相关。近年来，FOXP3的表达及其与预后的关系也在临床研究中在一些癌细胞中得到证实。然而，对于非小细胞肺癌（NSCLC），肿瘤FOXP3表达的预后意义及其与TcB的关系仍然未知。采用免疫组化方法检测87例NSCLC手术标本中癌细胞和肿瘤浸润淋巴细胞中FOXP3的表达。回顾性评估肿瘤浸润性Treg计数和肿瘤FOXP3表达状态的预后价值。在87例患者中的27例（31.0%）中观察到FOXP3阳性癌细胞。Treg计数与肿瘤FOXP3状态之间无显著相关性。Treg计数增加与总体和无复发生存期较差相关，而肿瘤FOXP3状态对生存期的影响不显著。然而，当FOXP3阳性癌细胞存在时，Treg积累与预后不良之间的关系减弱。相比之下，没有肿瘤FOXP3表达和高Treg计数的患者的总体和无复发生存率显著低于其他组（风险比：分别为3.118和3.325，p = 0.028和0.024）。这些结果表明，肿瘤FOXP3表达在NSCLC中具有更好的预后潜力，并且与肿瘤浸润性Treg计数相结合，肿瘤FOXP3的缺乏允许选择高风险患者。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Expression of the transcription factor FOXP3 characterizes regulatory T cells (Tregs) that engage in the maintenance of immunological self-tolerance and immune homeostasis. Intra-tumoral accumulation of Tregs is associated with unfavorable prognosis in several kinds of cancers. Recently, expression of FOXP3 and its association with prognosis have also been shown in some cancer cells in clinical studies. For non-small cell lung cancer (NSCLC), however, prognostic significance of tumor FOXP3 expression and its relationship with Tregs remain unknown. FOXP3 expression in cancer cells and tumor-infiltrating lymphocytes was examined by immunohistochemical staining of surgical specimens from 87 patients with NSCLC. Prognostic values of the tumor-infiltrating Treg count and tumor FOXP3 expression status were evaluated retrospectively. FOXP3-positive cancer cells were observed in 27 of 87 (31.0%) patients. There was no significant relationship between Treg count and tumor FOXP3 status. Increased Treg counts were associated with worse overall and relapse-free survival whereas the influence of tumor FOXP3 status on survival was not significant. However, when FOXP3-positive cancer cells were present, the relationship between Treg accumulation and worse prognosis was attenuated. In contrast, patients without tumor FOXP3 expression and high Treg count had significantly worse overall and relapse-free survival (hazard ratio: 3.118 and 3.325, p = 0.028 and 0.024, respectively) than other groups. These results suggest that tumor FOXP3 expression has a better prognostic potential in NSCLC and that in combination with tumor-infiltrating Treg count the absence of tumor FOXP3 allows the selection of high-risk patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved.