Myocardial hypertrophy: the effect of sodium and the role of sympathetic nervous system activity.
Myocardial hypertrophy: the effect of sodium and the role of sympathetic nervous system activity.
复制标题
心肌肥厚：钠的作用和交感神经系统活动的作用。
DOI：
10.1093/ajh/1.1.11
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发表时间：
1988
影响因子：
3.2
通讯作者：
Goodman,AI
中科院分区：
文献类型：
--
作者：
Meggs,LG;Ben-Ari,J;Gammon,D;Goodman,AI
Dietary sodium and the myocardial α1-receptor have been implicated in the hypertrophic response of myocardial tissue. Alterations in sodium homeostasis have been demonstrated to influence sympathetic nervous function, centrally and peripherally. In this investigation, we have examined the effect of dietary sodium on the development of myocardial hypertrophy; and the role of sympathetic neuroeffector mechanisms in the hypertrophic response. Studies were performed in three groups of uninephrectomized rats: A–regular diet; B–1% saline/regular diet; C–1% Saline/doca/regular diet. Groups A and B did not develop systemic hypertension (SHT). Saline treatment increased heart weight and the density of surface α1-receptors; myocardial norepinephrine (NE) was reduced. Group C developed SHT. Heart weight was greatest in Group C; and myocardial NE was severely depleted. Downregulation of myocardial α1-receptors, a finding consistent with the hyperadrenergic state, was observed in Group C. Our results suggest dietary sodium may modulate hypertrophic response in myocardial tissue, by altering sympathetic neuroeffector mechanisms. Am J Hypertens 1:11–15, 1988
