FREQUENCIES OF COMPLEX DISEASES IN HYBRID POPULATIONS
FREQUENCIES OF COMPLEX DISEASES IN HYBRID POPULATIONS
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DOI：
10.1002/ajpa.1330700408
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发表时间：
1986-08-01
影响因子：
2.8
通讯作者：
WEISS, KM
中科院分区：
文献类型：
--
作者：
CHAKRABORTY, R;WEISS, KM
病因复杂的疾病在不同种族人群中的发病率有很大差异。非胰岛素依赖型糖尿病（NIDDM）、类风湿性关节炎和几种心血管疾病构成了这些疾病的实例。在涉及已知祖先的杂交群体的遗传研究中，比较疾病患病率与混合比例并将其关联是有意义的，混合比例是根据许多多态性遗传标记估计的。 理论公式提供了有关疾病的流行在混合人口的混合比例下不同的疾病传播模式。结果表明，混合比例和疾病频率之间的关系提供了歧视权力的遗传方式。通过比较墨西哥裔美国人中美洲印第安人血统的比例和NIDDM患病率的例子来说明这种方法。发现遗传因素参与了NIDDM的易感性，但遗传方式不能用任何简单的遗传模型来解释，并且不能完全排除散发事件的作用。
Diseases of complex etiology demonstrate considerable variation in their frequencies in different ethnic populations. Noninsulin-dependent diabetes mellitus (NIDDM), rheumatoid arthritis, and several cardiovascular diseases constitute examples of such disorders. In genetic studies involving hybrid populations of known ancestry, it is of interest to compare and correlate disease prevalence with the admixture proportion, the latter estimated from a number of polymorphic genetic markers. Theoretical formulations are provided relating disease prevalence in a hybrid population to the admixture proportion under different models of disease transmission. It is shown that the relationship between admixture proportion and disease frequency provides discriminatory power regarding the mode of inheritance. This method is illustrated with an example comparing the proportion of Amerindian ancestry in Mexican-Americans and the prevalence of NIDDM. It is found that genetic factors are involved in susceptibility to NIDDM, but the mode of inheritance cannot be explained by any simple genetic model, and the role of sporadic events cannot be totally ruled out.