Branched-chain amino acids, nitrogen excretion and injury in man.
Branched-chain amino acids, nitrogen excretion and injury in man.
复制标题
支链氨基酸、氮排泄和人体损伤。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
D. Williamson
中科院分区：
文献类型：
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作者：
J. Wedge;R. De Campos;A. Kerr;R. Smith;R. Farrell;V. Ilic;D. Williamson
1.静脉血中的支链氨基酸，缬氨酸，亮氨酸和异亮氨酸的浓度，尿氮排泄已被测定在16个成年男性，从2小时至7天后受伤，并在4个成年人后，选择性皮肤移植。2.在受伤组中，这些氨基酸的浓度在受伤后24小时显着上升，并在4天翻了一番，并保持高水平;相比之下，皮肤移植患者没有显着变化。3.在那些受伤的患者与初始高酮血症，定义为超过0-2 mmo 1/1，在受伤后的第四和第七天的支链氨基酸浓度的增加显着低于那些与normoketonaemia，并伴随着较低的尿氮排泄在整个期间。4.有人建议，损伤后支链氨基酸的浓度的变化表明减少肌肉或过度释放，由于蛋白质的合成和蛋白质catalysts之间的不平衡，在这个组织中的摄取。
1. Venous blood concentrations of the branched-chain amino acids, valine, leucine and isoleucine, and urinary nitrogen excretion have been measured in sixteen adult males, from 2 h to 7 days after injury, and in four adults after elective skin grafts. 2. In the injured group the concentrations of these amino acids rose significantly 24 h after injury and had doubled at 4 days and remained high; in contrast the skin-graft patients showed no significant change. 3. In those injured patients with initial hyperketonaemia, defined as more than 0-2 mmo1/1, the increase in concentrations of branched-chain amino acids at the fourth and seventh days after injury was significantly less than in those with normoketonaemia, and was accompanied by lower urinary nitrogen excretion throughout the whole period. 4. It is suggested that the changes in the concentration of branched-chain amino acids after injury indicate decreased uptake by muscle or excessive release due to an imbalance between protein synthesis and protein catabolism in this tissue.