Endocrine disrupting compounds: Can they target the immune system of fish?
Endocrine disrupting compounds: Can they target the immune system of fish?
复制标题
DOI：
10.1016/j.marpolbul.2011.05.007
复制
发表时间：
2011-01-01
影响因子：
5.8
通讯作者：
Segner, Helmut
中科院分区：
文献类型：
--
作者：
Casanova-Nakayama, Ayako;Wenger, Michael;Segner, Helmut
内分泌干扰，特别是雌激素活性化合物的干扰，已被确定为水生环境中一种重要的生态毒理学危害。关于内分泌干扰化合物对野生动物影响的研究主要集中在生殖系统的干扰上。然而，越来越多的证据表明，内分泌干扰物影响生殖系统以外的各种生理系统。在这里，我们讨论了内分泌干扰物是否能够影响鱼类的免疫系统，因为这将对个体健康和种群增长产生直接影响。表明雌激素在鱼类中具有免疫调节作用的证据来自以下发现：（a）雌激素受体在鱼类免疫器官中表达，（B）免疫基因表达受雌激素暴露的调节，以及（c）雌激素暴露下鱼类对病原体的易感性增加。(C)2011爱思唯尔有限公司保留所有权利。
Endocrine disruption, in particular disruption by estrogen-active compounds, has been identified as an important ecotoxicological hazard in the aquatic environment. Research on the impact of endocrine disrupting compounds (EDCs) on wildlife has focused on disturbances of the reproductive system. However, there is increasing evidence that EDCs affect a variety of physiological systems other than the reproductive system. Here, we discuss if EDCs may be able to affect the immune system of fish, as this would have direct implications for individual fitness and population growth. Evidence suggesting an immunomodulatory role of estrogens in fish comes from the following findings: (a) estrogen receptors are expressed in piscine immune organs, (b) immune gene expression is modulated by estrogen exposure, and (c) pathogen susceptibility of fish increases under estrogen exposure. (C) 2011 Elsevier Ltd. All rights reserved.