A generic bioheat transfer thermal model for a perfused tissue.

A generic bioheat transfer thermal model for a perfused tissue.
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DOI:
10.1115/1.3127260
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发表时间:
2009-07
期刊:
Journal of biomechanical engineering
影响因子:
--
通讯作者:
Vaughan JT
Vaughan JT
中科院分区:
其他
文献类型:
--
作者:
Shrivastava D;Vaughan JT

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需要热模型来预测灌注组织中的温度,其满足以下三个标准。第一,模型满足能量守恒。第二,从血管到组织的热传递速率建模,而不遵循血管路径。第三,该模型适用于任何未加热和加热的组织。为了满足这些标准,一个通用的生物热传递模型(BHTM),在这里通过保存热能加热,血管化,有限的组织,并通过一些简化的假设。两个线性,耦合微分方程得到以下两个变量:组织体积平均温度和血液体积平均温度。通用模型进行了比较,广泛采用的,经验Pennes的BHTM。比较表明,Pennes灌注项wCp(1−ε)应解释为局部血管依赖性传热系数项。建议进一步适应的一般BHTM特定组织使用成像技术和数值模拟。
A thermal model was needed to predict temperatures in a perfused tissue, which satisfied the following three criteria. One, the model satisfied conservation of energy. Two, the heat transfer rate from blood vessels to tissue was modeled without following a vessel path. Three, the model applied to any unheated and heated tissue. To meet these criteria, a generic bioheat transfer model (BHTM) was derived here by conserving thermal energy in a heated, vascularized, finite tissue and by making a few simplifying assumptions. Two linear, coupled differential equations were obtained with the following two variables: tissue volume averaged temperature and blood volume averaged temperature. The generic model was compared to the widely employed, empirical Pennes’ BHTM. The comparison showed that the Pennes’ perfusion term wCp(1−ε) should be interpreted as a local vasculature dependent heat transfer coefficient term. Suggestions are presented for further adaptations of the general BHTM for specific tissues using imaging techniques and numerical simulations.
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