Major depressive disorder is associated with attenuated cardiovascular reactivity and impaired recovery among those free of cardiovascular disease.
Major depressive disorder is associated with attenuated cardiovascular reactivity and impaired recovery among those free of cardiovascular disease.
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DOI：
10.1037/a0013001
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发表时间：
2009-03
影响因子：
4.2
通讯作者：
Rottenberg, Jonathan
中科院分区：
文献类型：
--
作者：
Salomon, Kristen;Clift, April;Karlsdottir, Mardis;Rottenberg, Jonathan
在诊断为重度抑郁症（MDD）的自然样本和健康对照参与者中检查心血管反应性和对实验室应激的恢复。前瞻性证据表明，MDD导致心血管疾病的风险等于或大于与抑郁情绪相关的风险。增强心血管反应性已被提出作为解释风险增加的机制，但数据不一致，是否抑郁症患者表现出增强或减弱的反应。此外，很少有研究探讨评价和恢复的差异。被诊断患有MDD的参与者（N = 25）和健康对照参与者（N = 25）参与了一项心血管反应性方案，包括两项任务，每项任务之后都有短暂的恢复期。评估血压、心率、射血前期、心输出量和总外周阻力。在每个任务之前评估任务的评价。抑郁的参与者表现出显着更低的收缩压，心率和心输出量的反应，在讲话时，心率反应较少的镜像跟踪和较少的心率恢复后的讲话和镜像跟踪比对照组。抑郁的参与者认为这些任务要求更高，更具威胁性，压力更大，并且报告说比对照组更难科普。评价与心率反应性相关，但评价并不介导抑郁组与反应性之间的关系。受损的恢复，而不是夸大的心血管反应可能部分解释增加的前瞻性心血管疾病的风险在抑郁症的个人。
To examine cardiovascular reactivity and recovery to laboratory stress among a naturalistic sample of individuals diagnosed with major depressive disorder (MDD) and healthy control participants. Prospective evidence suggests that MDD confers risk for cardiovascular disease equal to or greater than the risk associated with depressed mood. Enhanced cardiovascular reactivity has been proposed as a mechanism explaining increased risk, but data are inconsistent as to whether depressed individuals exhibit enhanced or attenuated reactivity. Further, few studies have examined appraisal and recovery differences. Participants diagnosed with MDD (N = 25) and healthy control participants (N = 25) engaged in a cardiovascular reactivity protocol including two tasks, each followed by a brief recovery period. Blood pressure, heart rate, pre-ejection period, cardiac output and total peripheral resistance were assessed. Appraisals of tasks were assessed prior to each task. Depressed participants exhibited significantly less systolic blood pressure, heart rate and cardiac output reactivity during speech, less heart rate reactivity during mirror tracing and less heart rate recovery after speech and mirror tracing than controls. Depressed participants appraised the tasks as more demanding, threatening, and stressful and reported being less able to cope than controls. Appraisals were related to heart rate reactivity, but appraisals did not mediate the relationship between depression group and reactivity. Impaired recovery rather than exaggerated cardiovascular reactivity may partially explain the increased prospective cardiovascular disease risk in depressed individuals.
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影响因子：
7.6
作者：
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通讯作者：
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