DEMENTIA OF THE ALZHEIMER TYPE AND MULTI-INFARCT DEMENTIA - A CLINICAL DESCRIPTION AND DIAGNOSTIC PROBLEMS
DEMENTIA OF THE ALZHEIMER TYPE AND MULTI-INFARCT DEMENTIA - A CLINICAL DESCRIPTION AND DIAGNOSTIC PROBLEMS
复制标题
DOI：
10.1111/j.1532-5415.1984.tb02233.x
复制
发表时间：
1984-01-01
影响因子：
6.3
通讯作者：
WINBLAD, B
中科院分区：
文献类型：
--
作者：
BUCHT, G;ADOLFSSON, R;WINBLAD, B
将患有阿尔茨海默病、阿尔茨海默型老年痴呆（AD/SDAT）或多梗死性痴呆（MID）的患者与对照组进行比较。痴呆患者的痴呆程度和病程大致相同。MID组的平均年龄明显高于AD/SDAT组。AD/SDAT患者中63%无其他疾病，而MID患者中65%有心血管疾病。在MID患者中，30%有抑郁症病史，而AD/SDAT患者中只有5%有抑郁症病史。在调查时，AD/SDAT患者明显比MID患者表现出更多的抑郁症状。70%的MID患者有局灶性神经系统体征，而AD/SDAT患者只有6%。所有AD/SDAT患者心电图正常，而75%的MID患者心电图异常。79%的AD/SDAT患者脑电图显示广泛性慢频，65%的MID患者脑电图显示局域性慢频和异常。大脑计算机断层扫描显示，MID患者心室系统扩张明显更大，而皮层萎缩在3组之间无显著差异。与对照组相比，AD/SDAT组脑脊液中的同型香草酸明显降低。
Patients who had Alzheimer''s disease, senile dementia of the Alzheimer type (AD/SDAT) or multi-infarct dementia (MID), were compared with a group of controls. Demented patients had approximately the same degree of dementia and the same duration of illness. The MID group had a significantly higher mean age than the AD/SDAT group. Of the AD/SDAT patients 63% were free of other diseases, while 65% of the MID patients had cardiovascular disease. Of the MID patients, 30% had a history of previous depression, while only 5% of the AD/SDAT patients had had depression. At the time of the investigation AD/SDAT patients showed significantly more signs of depression than the MID patients. Focal neurologic signs were found in 70% of the MID patients and only 6% of the AD/SDAT patients. The ECG was normal for every AD/SDAT patient, wile 75% of the MID patients had abnormal ECG. EEG showed generalized slow frequencies in 79% of the AD/SDAT patients and localized slow frequencies and abnormalities in 65% of the MID patients. Computed tomography of the brain showed that MID patients had significantly greater dilation of the ventricular system, while cortical atrophy did not differ significantly among the 3 groups. Homovanillic acid in the CSF was significantly lower in the AD/SDAT group as compared with controls.