Mono‐ O ‐functionalizations of Pittsburgh Green and Their Applications
Mono‐ O ‐functionalizations of Pittsburgh Green and Their Applications
复制标题
匹兹堡绿的Mono-O-功能化及其应用
DOI：
10.1002/ejoc.202200343
复制
发表时间：
2022
影响因子：
2.8
通讯作者：
Koide, Kazunori
中科院分区：
文献类型：
--
作者：
Vinod, Jincy K.;Koide, Kazunori
以前用于制备非荧光荧光素的合成策略主要限于简单烯烃和炔烃的双加成。我们报告了匹兹堡绿色对其单烷基化或酯化化合物的一步掩蔽。与以前的合成不同，这种策略容许更广泛的官能团作为掩蔽基团。我们还证明了单烷基化在金属检测方面优于二烷基化。
The previous synthetic strategy for the preparation of non‐fluorescent fluoresceins was mostly limited to the double addition of simple alkenes and alkynes. We report the one‐step masking of Pittsburgh Green to its mono‐alkylated or esterified compounds. Unlike previous syntheses, this strategy tolerates a broader range of functional groups as masking groups. We also demonstrate the advantage of mono‐alkylation over di‐alkylation for metal detection.