Paraneoplastic cutaneous manifestations: concepts and updates*
Paraneoplastic cutaneous manifestations: concepts and updates*
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DOI：
10.1590/s0365-05962013000100001
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发表时间：
2013-02-01
影响因子：
1.7
通讯作者：
Campbell, Iphis Tenfuss
中科院分区：
文献类型：
--
作者：
Silva, Josenilson Antônio da;Mesquita, Kleyton de Carvalho;Campbell, Iphis Tenfuss
皮肤常常发出全身变化的信号。一些影响内脏器官的肿瘤性疾病可能会引发多种皮肤表现。尽管这些皮肤病相对不常见，但识别一些典型的副肿瘤性皮肤病可能有助于肿瘤的早期诊断并确定更好的预后。在这篇综述文章中，我们讨论了与肿瘤密切相关的副肿瘤性皮肤表现，包括恶性黑棘皮病、掌肚、匍匐回状红斑、Bazex综合征、获得性多毛症、松毛症、坏死性游走性红斑、Leser-Trelat征和副肿瘤性天疱疮。我们还回顾了每种疾病的临床表现，并包括有关疾病发病机制的最新知识。
The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Although these dermatoses are relatively unusual, the recognition of some typical paraneoplastic dermatoses may lead to the early diagnosis of a neoplasm and determine a better prognosis. In this review article, we discuss the paraneoplastic cutaneous manifestations strongly associated with neoplasms, which include acanthosis nigricans maligna, tripe palms, erythema gyratum repens, Bazex syndrome, acquired hypertrichosis lanuginosa, necrolytic migratory erythema, Leser-Trelat sign and paraneoplastic pemphigus. We also review the clinical manifestations of each condition and include updated knowledge on disease pathogenesis.