AUTOIMMUNE MURINE THYROIDITIS RELATION TO HISTOCOMPATIBILITY (H-2) TYPE
AUTOIMMUNE MURINE THYROIDITIS RELATION TO HISTOCOMPATIBILITY (H-2) TYPE
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DOI：
10.1126/science.174.4014.1137
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发表时间：
1971-01-01
期刊：
影响因子：
56.9
通讯作者：
ROSE, NR
中科院分区：
文献类型：
--
作者：
VLADUTIU, AO;ROSE, NR
用完全弗氏佐剂乳化的甲状腺提取物免疫33个近交系小鼠，显示甲状腺自身抗体反应和自身免疫性甲状腺损伤的差异，与菌株的组织相容性（H-2）类型有关。同类小鼠相同的H-2型表现出相同的模式的抗体反应和甲状腺炎，无论菌株的遗传背景，从而显示组织相容性决定簇和自身免疫之间的密切关系。
Immunization of 33 inbred strains of mice with thyroid extract emulsified in complete Freund's adjuvant showed differences in both thyroid autoantibody response and autoimmune thyroid damage, related to the histocompatibility (H-2) type of the strain. Congenic mice of the same H-2 type exhibited the same pattern of antibody response and thyroiditis, regardless of the strain's genetic background, thus showing a close relation between histocompatibility determinants and autoimmunity.