Expedient total synthesis of pyrrothine natural products and analogs
Expedient total synthesis of pyrrothine natural products and analogs
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DOI：
10.1039/b616411k
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发表时间：
2007-01-01
影响因子：
3.2
通讯作者：
Nielsen, John
中科院分区：
文献类型：
--
作者：
Hjelmgaard, Thomas;Givskov, Michael;Nielsen, John
本文描述了两种pyrothine天然产物holomycin 1a（7步，总体11%）和xenorhabdin i1c（7步，总体11%）及其类似物通过一个共同的后期中间体的便利和直接的全合成。该途径通过盐酸吡虫氨酸中间体10进行（6步，总体17%），这也使得类似物的合成非常快速，如1f， 1g和1h的合成（7步，总体11 - 12%）。
This paper describes an expedient and straightforward total synthesis of the two pyrrothine natural products holomycin 1a ( 7 steps, 11% overall) and xenorhabdin I 1c ( 7 steps, 11% overall) and analogs thereof via a common late-stage intermediate. The pathway proceeds via the pyrrothine hydrochloride intermediate 10 ( 6 steps, 17% overall) which also gave access to very fast synthesis of analogs as demonstrated by the synthesis of 1f, 1g and 1h ( 7 steps, 11 - 12% overall).